Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.
Eur J Immunol. 2010 Aug;40(8):2123-30. doi: 10.1002/eji.201040630.
DC initiate and regulate T-cell immunity and are thus the key to optimization of all types of vaccines. Insights into DC biology offer many opportunities to enhance immunogenicity. In this Viewpoint, I discuss some recent developments and findings that are of immediate relevance for the clinical development of cancer vaccines. In addition, I emphasize my personal view that we should explore the potential of adoptively transferred DC (i.e. DC vaccination) as cancer vaccines by performing two-armed trials that address critical variables and by delivering antigens via mRNA-transfected DC.
树突状细胞（DC）启动并调节 T 细胞免疫，因此是优化所有类型疫苗的关键。对 DC 生物学的深入了解为提高免疫原性提供了许多机会。在本观点中，我讨论了一些最近的发展和发现，这些发现对癌症疫苗的临床开发具有直接的意义。此外，我强调了我的个人观点，即我们应该通过进行双管齐下的试验来解决关键变量，并通过转染 mRNA 的 DC 来传递抗原，以探索过继转移的 DC（即 DC 疫苗接种）作为癌症疫苗的潜力。
