通过RNA干扰敲低HdmX或Hdm2可带来对p53信号传导的新见解。 - Suppr

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超能文献

RNAi knockdown of HdmX or Hdm2 leads to new insights into p53 signaling.

作者信息

Berberich Steven J

机构信息

Biochemistry and Molecular Biology Department, Wright State University, Dayton, OH, USA.

出版信息

Cell Cycle. 2010 Sep 15;9(18):3640-1. doi: 10.4161/cc.9.18.13255. Epub 2010 Sep 4.

DOI:10.4161/cc.9.18.13255

PMID:20855947

Abstract

摘要

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RNAi knockdown of HdmX or Hdm2 leads to new insights into p53 signaling.

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N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.

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Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study.

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Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus.

Exp Cell Res. 2024 Aug 15;441(2):114185. doi: 10.1016/j.yexcr.2024.114185. Epub 2024 Jul 26.

HdmX overexpression inhibits oncogene induced cellular senescence.

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c-Abl phosphorylates Hdmx and regulates its interaction with p53.

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引用本文的文献

The protein p17 signaling pathways in cancer.

Tumour Biol. 2013 Dec;34(6):4081-7. doi: 10.1007/s13277-013-0999-1. Epub 2013 Jul 31.

Mdm2 and MdmX as Regulators of Gene Expression.

Genes Cancer. 2012 Mar;3(3-4):264-73. doi: 10.1177/1947601912455331.

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相似文献

RNAi knockdown of HdmX or Hdm2 leads to new insights into p53 signaling.

Cell Cycle. 2010 Sep 15;9(18):3640-1. doi: 10.4161/cc.9.18.13255. Epub 2010 Sep 4.

Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53.

Aging (Albany NY). 2009 Jan;1(1):89-108. doi: 10.18632/aging.100008.

HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

J Biol Chem. 2010 Sep 17;285(38):29111-27. doi: 10.1074/jbc.M110.129726. Epub 2010 Jul 20.

Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.

Bioorg Med Chem. 2010 Aug 15;18(16):6099-108. doi: 10.1016/j.bmc.2010.06.053. Epub 2010 Jun 22.

N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.

Bioorg Med Chem. 2009 Dec 1;17(23):7884-93. doi: 10.1016/j.bmc.2009.10.032. Epub 2009 Oct 21.

p53 promotes its own polyubiquitination by enhancing the HDM2 and HDMX interaction.

Protein Sci. 2018 May;27(5):976-986. doi: 10.1002/pro.3405. Epub 2018 Mar 25.

Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study.

FEBS J. 2022 Sep;289(17):5341-5358. doi: 10.1111/febs.16433. Epub 2022 Mar 28.

Hdm2 disrupts HdmX-mediated nuclear export of p53 by sequestering it in nucleus.

Exp Cell Res. 2024 Aug 15;441(2):114185. doi: 10.1016/j.yexcr.2024.114185. Epub 2024 Jul 26.

HdmX overexpression inhibits oncogene induced cellular senescence.

Cell Cycle. 2010 Aug 15;9(16):3376-82. doi: 10.4161/cc.9.16.12779. Epub 2010 Aug 23.

c-Abl phosphorylates Hdmx and regulates its interaction with p53.

J Biol Chem. 2009 Feb 6;284(6):4031-9. doi: 10.1074/jbc.M809211200. Epub 2008 Dec 15.

引用本文的文献

The protein p17 signaling pathways in cancer.

Tumour Biol. 2013 Dec;34(6):4081-7. doi: 10.1007/s13277-013-0999-1. Epub 2013 Jul 31.

Mdm2 and MdmX as Regulators of Gene Expression.

Genes Cancer. 2012 Mar;3(3-4):264-73. doi: 10.1177/1947601912455331.