钆增强磁共振成像研究肝硬化肝脏的门静脉期和延迟期对检测高血供肝细胞癌对比剂廓清的比较。

Comparison of portal venous and delayed phases of gadolinium-enhanced magnetic resonance imaging study of cirrhotic liver for the detection of contrast washout of hypervascular hepatocellular carcinoma.

作者信息

Cereser Lorenzo, Furlan Alessandro, Bagatto Daniele, Girometti Rossano, Como Giuseppe, Avellini Claudio, Orsaria Maria, Zuiani Chiara, Bazzocchi Massimo

机构信息

Institute of Diagnostic Radiology, University of Udine, Udine, Italy.

出版信息

J Comput Assist Tomogr. 2010 Sep-Oct;34(5):706-11. doi: 10.1097/RCT.0b013e3181e1a88e.

DOI:10.1097/RCT.0b013e3181e1a88e

PMID:20861773

Abstract

OBJECTIVE

To retrospectively compare portal venous phase (PVP) and delayed phase (DP) for the detection of tumor washout at gadobenate dimeglumine-enhanced liver magnetic resonance imaging (MRI) in cirrhotic patients with hypervascular hepatocellular carcinoma (HCC).

METHODS

Thirty-three patients with 55 HCCs underwent 1.5-T MRI by means of fat-suppressed T1-weighted sequence obtained before and after gadobenate dimeglumine administration, during early and late arterial phases, PVP (70 seconds), and DP (180 seconds). Detection rates of contrast washout of hypervascular HCCs and tumor-to-liver contrast on PVP and DP were measured and compared.

RESULTS

Among 54 hypervascular HCCs, washout was present in 24 (44%) of 54 tumors on PVP and in 44 (82%) of 54 on DP (P < 0.001). In 20 (37%) of 54 tumors, washout was deemed present only on DP. Delayed phase images yielded significantly higher mean tumor-to-liver contrast absolute values compared with PVP images (-24.5 [56.1] vs -9.3 [52.6], P = 0.001).

CONCLUSIONS

Delayed phase is superior to PVP for the washout detection of hypervascular HCC at gadobenate dimeglumine-enhanced MRI of cirrhotic liver.

摘要

目的

回顾性比较钆贝葡胺增强肝脏磁共振成像（MRI）中门静脉期（PVP）和延迟期（DP）对肝硬化伴高血供肝细胞癌（HCC）患者肿瘤廓清的检测情况。

方法

33例患有55个HCC的患者接受了1.5-T MRI检查，采用钆贝葡胺给药前后获得的脂肪抑制T1加权序列，包括动脉早期和晚期、门静脉期（70秒）和延迟期（180秒）。测量并比较高血供HCC的对比剂廓清率以及门静脉期和延迟期的肿瘤与肝脏对比。

结果

在54个高血供HCC中，54个肿瘤中有24个（44%）在门静脉期出现廓清，54个中有44个（82%）在延迟期出现廓清（P<0.001）。在54个肿瘤中的20个（37%）中，仅在延迟期出现廓清。与门静脉期图像相比，延迟期图像产生的平均肿瘤与肝脏对比绝对值显著更高（-24.5 [56.1]对-9.3 [52.6]，P = 0.001）。