Fan Hong-bin, Wang Yi-nan, Geng De-qin
Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jul;26(7):712-3.
To poly ADP ribose polymerase inhibitors PJ34 on glutamate neurotoxicity induced protective effect, as PJ34 in ischemic cerebrovascular disease provide a reference for clinical applications.
After the cultured HT-22 cells were treated with 5 mmol/L Glu induction treatment, divided into the PJ34 group subsequently given 50 micromol/L PARP inhibitor PJ34 protection effects processing. Inhibition rate of each group and the PARP activity of changes.
PJ34 group after 24 h, inhibition rate of HT-22 cells were markedly decreased (P<0.05). PJ34 PARP activity than the control group was significantly lower (P<0.05).
PJ34 PARP activity by reducing increased glutamate-induced HT-22 cell viability, and thus play a protective effect on cells.
探讨聚 ADP 核糖聚合酶抑制剂 PJ34 对谷氨酸神经毒性的保护作用，为 PJ34 在缺血性脑血管病中的临床应用提供参考。
将培养的 HT-22 细胞用 5 mmol/L 谷氨酸诱导处理后，分为 PJ34 组，随后给予 50 μmol/L PARP 抑制剂 PJ34 进行保护作用处理。观察各组细胞的抑制率及 PARP 活性变化。
PJ34 组作用 24 h 后，HT-22 细胞抑制率明显降低（P<0.05）。PJ34 组 PARP 活性较对照组明显降低（P<0.05）。
PJ34 通过降低 PARP 活性增加谷氨酸诱导的 HT-22 细胞活力，从而对细胞起到保护作用。
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