[苯并异硒唑啉酮及其衍生物，一类新型抗炎和抗氧化剂]
[Benzisoselenazolinones and their derivatives, a new series of anti-inflammatories and antioxidants].
作者信息
Renson M, Dereu N
机构信息
Université de Liège, Service de Chimie Organique, Belgique.
出版信息
J Pharm Belg. 1990 Sep-Oct;45(5):322-30.
PMID:2086756
Abstract
Ebselen, a benzisoselenazolinone, displays antiinflammatory properties and antioxidant capacity similar to the enzyme glutathione peroxydase. Structural modifications were realized. The presence of substituents ortho to selenium, and in particular of a dipolar group such as -NO2, led to an interesting modification of the pharmacological properties.
摘要
依布硒啉，一种苯并异硒唑啉酮，具有与谷胱甘肽过氧化物酶相似的抗炎特性和抗氧化能力。已进行了结构修饰。硒邻位取代基的存在，特别是像 -NO2 这样的偶极基团的存在，导致了药理学性质的有趣改变。
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[Benzisoselenazolinones and their derivatives, a new series of anti-inflammatories and antioxidants].[苯并异硒唑啉酮及其衍生物，一类新型抗炎和抗氧化剂]
J Pharm Belg. 1990 Sep-Oct;45(5):322-30.
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