肌球蛋白节点聚集成收缩环的动力学。
Kinetics of myosin node aggregation into a contractile ring.
机构信息
Department of Physics, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
出版信息
Phys Rev Lett. 2010 Jul 23;105(4):048102. doi: 10.1103/PhysRevLett.105.048102. Epub 2010 Jul 20.
Abstract
We study a stochastic aggregation model for the assembly of the contractile ring from a broad band of nodes during cytokinesis in fission yeast. We found that bands of nodes condense into rings when the range of node interactions is larger than the width of the band. Wide bands are unstable to clump formation due to Poisson density fluctuations. We derive expressions for node kinetics and times for ring vs clump formation and test them using numerical simulations. These results suggest clump formation mechanisms in mutant cells.
摘要
我们研究了有丝分裂过程中分裂酵母中收缩环从广泛节点带中的组装的随机聚集模型。我们发现，当节点相互作用的范围大于带的宽度时，节点带会凝聚成环。由于泊松密度波动，宽带是不稳定的，容易形成团块。我们推导了节点动力学和环与团块形成的时间表达式，并使用数值模拟进行了测试。这些结果表明了突变细胞中团块形成的机制。
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