Wynne Katie, Field Benjamin Ct, Bloom Stephen R
Imperial College London, Department of Metabolic Medicine, Hammersmith Hospital, UK.
Curr Opin Investig Drugs. 2010 Oct;11(10):1151-7.
Oxyntomodulin, a product of the proglucagon gene, is released from the enteroendocrine L-cells of the gastrointestinal tract after the digestion of food, and acts via glucagon-like peptide 1 receptors in the arcuate nucleus to induce satiety. The administration of oxyntomodulin to animals and humans causes weight loss by reducing food intake in combination with increasing energy expenditure. Thus, the development of potent and long-acting analogs of oxyntomodulin is an exciting new therapeutic avenue for addressing the global obesity epidemic. This review discusses the role of oxyntomodulin in the physiological control of appetite, and presents the currently available evidence suggesting its potential as an obesity treatment.
胃泌酸调节素是胰高血糖素原基因的产物,在食物消化后从胃肠道的肠内分泌L细胞释放出来,并通过弓状核中的胰高血糖素样肽1受体发挥作用以诱导饱腹感。给动物和人类施用胃泌酸调节素可通过减少食物摄入量并增加能量消耗来导致体重减轻。因此,开发强效且长效的胃泌酸调节素类似物是应对全球肥胖流行的一个令人兴奋的新治疗途径。本综述讨论了胃泌酸调节素在食欲生理控制中的作用,并展示了目前表明其作为肥胖治疗方法潜力的现有证据。