胃癌的黏蛋白表型和胃型分化性腺癌的临床病理学。
Mucin phenotype of gastric cancer and clinicopathology of gastric-type differentiated adenocarcinoma.
出版信息
World J Gastroenterol. 2010 Oct 7;16(37):4634-9. doi: 10.3748/wjg.v16.i37.4634.
Abstract
Differentiated adenocarcinoma of the stomach is classified into gastric or intestinal phenotypes based on mucus expression. Recent advances in mucin histochemistry and immunohistochemistry have highlighted the importance of such a distinction, and it is important clinically to distinguish between gastric- and intestinal-type differentiated adenocarcinoma. However, a clinical and pathological diagnosis of this type is often difficult in early gastric cancer because of histological similarities between a hyperplastic epithelium and low-grade atypia. Furthermore, determining tumor margins is often difficult, even with extensive preoperative examination. It is therefore critical to consider these diagnostic difficulties and different biological behaviors with high malignant potential when treating patients with gastric-type differentiated adenocarcinoma.
摘要
胃的肠型分化腺癌根据黏液表达分为胃型或肠型。黏液组织化学和免疫组织化学的最新进展突出了这种区分的重要性，临床上区分胃型和肠型分化腺癌很重要。然而，由于增生上皮和低级别异型增生之间的组织学相似性，早期胃癌的这种类型的临床和病理诊断往往很困难。此外，即使进行广泛的术前检查，确定肿瘤边界也常常很困难。因此，在治疗胃型分化腺癌患者时，必须考虑到这些诊断困难和具有高恶性潜能的不同生物学行为。
相似文献
1
Mucin phenotype of gastric cancer and clinicopathology of gastric-type differentiated adenocarcinoma.
World J Gastroenterol. 2010 Oct 7;16(37):4634-9. doi: 10.3748/wjg.v16.i37.4634.
2
Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha may complement mucin phenotype of differentiated-type early gastric carcinoma.
Pathol Int. 2009 Jul;59(7):462-70. doi: 10.1111/j.1440-1827.2009.02394.x.
3
The prognostic significance of the mucin phenotype of gastric adenocarcinoma and its relationship with histologic classifications.
Oncol Rep. 2009 Feb;21(2):387-93.
4
Loss of phenotypic expression is related to tumour progression in early gastric differentiated adenocarcinoma.
Histopathology. 2005 Oct;47(4):357-67. doi: 10.1111/j.1365-2559.2005.02242.x.
5
[Mucin histochemical study of differentiated adenocarcinoma of stomach].
Nihon Shokakibyo Gakkai Zasshi. 1994 Apr;91(4):839-48.
6
Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren's histologic subtypes of gastric carcinomas.
Eur J Histochem. 2006 Oct-Dec;50(4):301-9.
7
Distinction of differentiated type early gastric carcinoma with gastric type mucin expression.
Cancer. 2000 Aug 15;89(4):724-32.
8
Re-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains.
Pathol Int. 2004 May;54(5):311-21. doi: 10.1111/j.1440-1827.2004.01625.x.
9
Mucin histochemical analysis of minute gastric differentiated adenocarcinoma.
Pathol Int. 1999 Jan;49(1):55-61. doi: 10.1046/j.1440-1827.1999.00824.x.
10
Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype: LI-cadherin is associated with intestinal phenotype.
Pathol Int. 2006 Apr;56(4):200-5. doi: 10.1111/j.1440-1827.2006.01946.x.
引用本文的文献
1
Endoscopic and clinicopathological features of early gastric papillary adenocarcinoma.
Front Oncol. 2024 Oct 30;14:1456520. doi: 10.3389/fonc.2024.1456520. eCollection 2024.
2
CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition.
Cell Death Differ. 2024 Oct;31(10):1302-1317. doi: 10.1038/s41418-024-01360-z. Epub 2024 Aug 20.
3
Mucin phenotype and microvessels in early gastic cancer: Magnifying endoscopy with narrow band imaging.
Heliyon. 2024 Jun 1;10(12):e32293. doi: 10.1016/j.heliyon.2024.e32293. eCollection 2024 Jun 30.
4
Unique immunohistochemical profiles of MUC5AC, MUC6, P53, and Ki67 in gastric atypical hyperplasia and dysplasia.
Int J Clin Exp Pathol. 2024 Mar 15;17(3):63-71. doi: 10.62347/JVIX8887. eCollection 2024.
5
Seven-Month Vitamin D Deficiency Inhibits Gastric Epithelial Cell Proliferation, Stimulates Acid Secretion, and Differentially Alters Cell Lineages in the Gastric Glands.
Nutrients. 2023 Nov 2;15(21):4648. doi: 10.3390/nu15214648.
6
PET-CT in Clinical Adult Oncology: III. Gastrointestinal Malignancies.
Cancers (Basel). 2022 May 27;14(11):2668. doi: 10.3390/cancers14112668.
7
Gastric mucin phenotype indicates aggressive biological behaviour in early differentiated gastric adenocarcinomas following endoscopic treatment.
Diagn Pathol. 2021 Jul 13;16(1):62. doi: 10.1186/s13000-021-01122-2.
8
Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study.
Virchows Arch. 2019 Nov;475(5):563-571. doi: 10.1007/s00428-019-02624-7. Epub 2019 Jul 22.
9
The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications.
Gastric Cancer. 2019 Nov;22(6):1130-1142. doi: 10.1007/s10120-019-00964-6. Epub 2019 Apr 15.
10
Characterization of human gastric adenocarcinoma cell lines established from peritoneal ascites.
Oncol Lett. 2018 Apr;15(4):4849-4858. doi: 10.3892/ol.2018.7995. Epub 2018 Feb 8.
本文引用的文献
1
Differentiated adenocarcinoma with a gastric phenotype in the stomach: difficulties in clinical and pathological diagnoses.
Clin J Gastroenterol. 2009 Aug;2(4):268-274. doi: 10.1007/s12328-009-0090-z. Epub 2009 May 29.
2
Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background.
Clin Cancer Res. 2006 Nov 1;12(21):6469-79. doi: 10.1158/1078-0432.CCR-06-1339.
3
Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations.
World J Gastroenterol. 2006 Jun 28;12(24):3803-9. doi: 10.3748/wjg.v12.i24.3803.
4
Extremely well-differentiated adenocarcinoma of the stomach: clinicopathological and immunohistochemical features.
World J Gastroenterol. 2006 Apr 28;12(16):2510-6. doi: 10.3748/wjg.v12.i16.2510.
5
Relationship between biological behavior and phenotypic expression in undifferentiated-type gastric carcinomas.
Gastric Cancer. 2005;8(4):220-7. doi: 10.1007/s10120-005-0340-9.
6
Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers--a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas.
Mod Pathol. 2004 Oct;17(10):1223-34. doi: 10.1038/modpathol.3800170.
7
Re-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains.
Pathol Int. 2004 May;54(5):311-21. doi: 10.1111/j.1440-1827.2004.01625.x.
8
THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.
Acta Pathol Microbiol Scand. 1965;64:31-49. doi: 10.1111/apm.1965.64.1.31.
9
Time trends for small gastric cancer in Japan.
Gastric Cancer. 2000 Dec 27;3(3):123-127. doi: 10.1007/pl00011705.
10
Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas.
Hum Pathol. 2002 Jan;33(1):80-6. doi: 10.1053/hupa.2002.30182.
Zotero 插件