[The effect of hypothalamic factors on the proliferation and cell differentiation of adenohypophyseal glandular epithelium implanted into the anterior chamber of the eye].

The purpose was to determine the effect of a complex of factors of large cell (supraoptic, paraventricular) or small cell (arcuate) hypothalamic nuclei on adenohypophyseal proliferation and cytodifferentiation, manifested in body tissue culture. Experiments were staged on 80 hypophysectomized random bred albino male rats with a body mass of 200-230 g. The evaluation of cell types of adenocytes was performed at stages of implantation every 12h-26 days with the help of light optic, electron microscopic, histoautoradiographic, immunohistochemical and radioimmunoassay methods. Supraoptic and paraventricular nuclei were shown to provide for the stimulation of adenocytic proliferation. The factors of paraventricular nuclei enhanced secretion in somato-, mammo-, thyro- and corticotropocytes and created conditions for their secondary cytodifferentiation.