种植前因素对经会阴前列腺间质内 125I 游离籽植入后 CT 测定前列腺体积和 CT/TRUS 体积比的影响。

Preimplant factors affecting postimplant CT-determined prostate volume and the CT/TRUS volume ratio after transperineal interstitial prostate brachytherapy with 125I free seeds.

机构信息

Department of Radiology, Keio University School of Medicine, Tokyo, Japan.

出版信息

Radiat Oncol. 2010 Sep 28;5:86. doi: 10.1186/1748-717X-5-86.

DOI:10.1186/1748-717X-5-86

PMID:20875137

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2954882/

Abstract

BACKGROUND

The aim was to identify preimplant factors affecting postimplant prostate volume and the increase in prostate volume after transperineal interstitial prostate brachytherapy with 125I free seeds.

METHODS

We reviewed the records of 180 patients who underwent prostate brachytherapy with 125I free seeds for clinical T1/T2 prostate cancer. Eighty-one (45%) of the 180 patients underwent neoadjuvant hormonal therapy. No patient received supplemental external beam radiotherapy. Postimplant computed tomography was undertaken, and postimplant dosimetric analysis was performed. Univariate and multivariate analyses were performed to identify preimplant factors affecting postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

RESULTS

Preimplant prostate volume by transrectal ultrasound, serum prostate-specific antigen, number of needles, and number of seeds implanted were significantly correlated with postimplant prostate volume by computed tomography. The increase in prostate volume after implantation was significantly higher in patients with neoadjuvant hormonal therapy than in those without. Preimplant prostate volume by transrectal ultrasound, number of needles, and number of seeds implanted were significantly correlated with the increase in prostate volume after implantation. Stepwise multiple linear regression analysis showed that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy were significant independent factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

CONCLUSIONS

The results of the present study show that preimplant prostate volume by transrectal ultrasound and neoadjuvant hormonal therapy are significant preimplant factors affecting both postimplant prostate volume by computed tomography and the increase in prostate volume after implantation.

摘要

背景

本研究旨在确定影响经会阴放射性碘 125 粒子间质内前列腺近距离治疗后前列腺体积及治疗后前列腺体积增加的术前因素。

方法

我们回顾了 180 例经会阴放射性碘 125 粒子间质内前列腺近距离治疗的临床 T1/T2 期前列腺癌患者的临床资料。81 例（45%）患者接受了新辅助内分泌治疗。所有患者均未接受外照射放疗。术后均行 CT 检查，进行前列腺剂量学分析。采用单因素和多因素分析来确定经直肠超声测量的术前前列腺体积、前列腺特异抗原、植入针数和植入碘 125 粒子数与术后 CT 测量的前列腺体积及术后前列腺体积增加的关系。

结果

经直肠超声测量的前列腺体积、前列腺特异抗原、植入针数和植入碘 125 粒子数与术后 CT 测量的前列腺体积相关，而新辅助内分泌治疗与术后前列腺体积增加显著相关。经直肠超声测量的前列腺体积、植入针数和植入碘 125 粒子数与术后前列腺体积增加显著相关。多元逐步线性回归分析显示，经直肠超声测量的前列腺体积和新辅助内分泌治疗是影响术后 CT 测量的前列腺体积和术后前列腺体积增加的独立因素。