Suppr超能文献

肌醇多磷酸 5-磷酸酶的缺失是皮肤鳞状细胞癌发生的早期事件。

Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.

机构信息

Mayo Clinic College of Medicine, Scottsdale, Arizona, USA.

出版信息

Cancer Prev Res (Phila). 2010 Oct;3(10):1277-83. doi: 10.1158/1940-6207.CAPR-10-0058. Epub 2010 Sep 28.

Abstract

Cutaneous squamous cell carcinoma (SCC) occurs commonly and can metastasize. Identification of specific molecular aberrations and mechanisms underlying the development and progression of cutaneous SCC may lead to better prognostic and therapeutic approaches and more effective chemoprevention strategies. To identify genetic changes associated with early stages of cutaneous SCC development, we analyzed a series of 40 archived skin tissues ranging from normal skin to invasive SCC. Using high-resolution array-based comparative genomic hybridization, we identified deletions of a region on chromosome 10q harboring the INPP5A gene in 24% of examined SCC tumors. Subsequent validation by immunohistochemistry on an independent sample set of 71 SCC tissues showed reduced INPP5A protein levels in 72% of primary SCC tumors. Decrease in INPP5A protein levels seems to be an early event in SCC development, as it also is observed in 9 of 26 (35%) examined actinic keratoses, the earliest stage in SCC development. Importantly, further reduction of INPP5A levels is seen in a subset of SCC patients as the tumor progresses from primary to metastatic stage. The observed frequency and pattern of loss indicate that INPP5A, a negative regulator of inositol signaling, may play a role in development and progression of cutaneous SCC tumors.

摘要

皮肤鳞状细胞癌(SCC)较为常见,且可能发生转移。鉴定皮肤 SCC 发生和发展过程中特定的分子异常和机制,可能会为预后和治疗方法提供更好的选择,并制定出更有效的化学预防策略。为了鉴定与皮肤 SCC 早期发展相关的遗传变化,我们分析了 40 个存档的皮肤组织,范围从正常皮肤到侵袭性 SCC。通过使用高分辨率基于阵列的比较基因组杂交技术,我们鉴定出在 24%的检查 SCC 肿瘤中,10q 染色体上包含 INPP5A 基因的区域存在缺失。随后,在 71 例 SCC 组织的独立样本集上通过免疫组织化学进行验证,显示在 72%的原发性 SCC 肿瘤中 INPP5A 蛋白水平降低。INPP5A 蛋白水平的降低似乎是 SCC 发展的早期事件,因为在 SCC 发展的最早阶段,即 26 例光化性角化病中的 9 例中也观察到了这种情况。重要的是,在一部分 SCC 患者中,随着肿瘤从原发性进展到转移性阶段,INPP5A 水平进一步降低。观察到的缺失频率和模式表明,INPP5A 是一种肌醇信号的负调节剂,可能在皮肤 SCC 肿瘤的发生和发展中发挥作用。

相似文献

1
Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.
Cancer Prev Res (Phila). 2010 Oct;3(10):1277-83. doi: 10.1158/1940-6207.CAPR-10-0058. Epub 2010 Sep 28.
2
Prognostic value of inositol polyphosphate-5-phosphatase expression in recurrent and metastatic cutaneous squamous cell carcinoma.
J Am Acad Dermatol. 2020 Apr;82(4):846-853. doi: 10.1016/j.jaad.2019.08.027. Epub 2019 Aug 19.
3
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma.
J Am Acad Dermatol. 2019 Mar;80(3):626-632.e1. doi: 10.1016/j.jaad.2018.10.018. Epub 2018 Oct 22.
5
L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
J Dermatol Sci. 2011 Sep;63(3):164-72. doi: 10.1016/j.jdermsci.2011.06.001. Epub 2011 Jun 22.
10

引用本文的文献

1
INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas.
Nat Cancer. 2024 Mar;5(3):481-499. doi: 10.1038/s43018-023-00710-z. Epub 2024 Jan 17.
2
INPP5A/HLA-G1/IL-10/MMP-21 Axis in Progression of Esophageal Squamous Cell Carcinoma.
Iran Biomed J. 2022 Nov 1;26(6):440-53. doi: 10.52547/ibj.3716.
3
Inositol triphosphate signaling triggers lysosome biogenesis via calcium release from endoplasmic reticulum stores.
Contact (Thousand Oaks). 2022 Jan;5:251525642210970. doi: 10.1177/25152564221097052. Epub 2022 May 31.
5
Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma.
PLoS One. 2019 Dec 20;14(12):e0223341. doi: 10.1371/journal.pone.0223341. eCollection 2019.
6
Prognostic value of inositol polyphosphate-5-phosphatase expression in recurrent and metastatic cutaneous squamous cell carcinoma.
J Am Acad Dermatol. 2020 Apr;82(4):846-853. doi: 10.1016/j.jaad.2019.08.027. Epub 2019 Aug 19.
7
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma.
J Am Acad Dermatol. 2019 Mar;80(3):626-632.e1. doi: 10.1016/j.jaad.2018.10.018. Epub 2018 Oct 22.
9
Frequent loss of inositol polyphosphate-5-phosphatase in oropharyngeal squamous cell carcinoma.
J Eur Acad Dermatol Venereol. 2018 Jan;32(1):e36-e37. doi: 10.1111/jdv.14462. Epub 2017 Aug 2.

本文引用的文献

1
Small-molecule inhibitors of the human epidermal receptor family.
Expert Opin Investig Drugs. 2009 Dec;18(12):1829-42. doi: 10.1517/13543780903373343.
3
KIT as a therapeutic target in melanoma.
J Invest Dermatol. 2010 Jan;130(1):20-7. doi: 10.1038/jid.2009.334.
4
Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma.
Am J Surg Pathol. 2009 Aug;33(8):1146-56. doi: 10.1097/PAS.0b013e3181a1ef36.
5
Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.
J Invest Dermatol. 2009 Jun;129(6):1562-8. doi: 10.1038/jid.2008.408. Epub 2009 Jan 8.
6
[Analysis of cytogenetic abnormalities in squamous cell carcinoma by array comparative genomic hybridization].
Actas Dermosifiliogr. 2008 Apr;99(3):199-206. doi: 10.1016/s1578-2190(08)70232-4.
8
Somatic activation of KIT in distinct subtypes of melanoma.
J Clin Oncol. 2006 Sep 10;24(26):4340-6. doi: 10.1200/JCO.2006.06.2984. Epub 2006 Aug 14.
9
Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization.
J Invest Dermatol. 2006 Oct;126(10):2308-15. doi: 10.1038/sj.jid.5700375. Epub 2006 May 25.
10
Efficient calculation of interval scores for DNA copy number data analysis.
J Comput Biol. 2006 Mar;13(2):215-28. doi: 10.1089/cmb.2006.13.215.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验