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小脑幕下和枕部开颅术中浅表颈丛阻滞用于过渡性镇痛:一项随机试验。

Superficial cervical plexus block for transitional analgesia in infratentorial and occipital craniotomy: a randomized trial.

机构信息

Department of Anesthesia, Centre Hospitalier Universitaire de Montréal, Hôpital Notre-Dame, QC, Canada.

出版信息

Can J Anaesth. 2010 Dec;57(12):1065-70. doi: 10.1007/s12630-010-9392-3. Epub 2010 Sep 28.

Abstract

BACKGROUND

In this study, we compared the quality of transitional analgesia provided by bilateral superficial cervical plexus block (SCPB) or morphine following a remifentanil-based anesthesia for infratentorial or occipital craniotomy.

METHODS

In this randomized controlled and double-blind study, 30 patients scheduled for infratentorial or occipital craniotomy were divided randomly into two groups: group morphine (morphine 0.1 mg·kg⁻¹ iv after dural closure and a SCPB performed with 20 mL of 0.9% saline at the end of the surgery) or group block (10 mL of 0.9% saline iv instead of morphine after dural closure and a SCPB performed with 20 mL of a 1:1 mixture of 0.5% bupivacaine and 2% lidocaine at the end of the surgery). Postoperative pain was assessed at one, two, four, eight, 12, 16, and 24 hr using an 11-point (0-10) numerical rating scale (NRS). Analgesia was provided with subcutaneous codeine.

RESULTS

Average NRS scores were similar between the two groups at each time interval over the study period. The average scores (with 95% confidence interval) were 3.9 (3.4-4.4) and 4.3 (3.8-4.9) for the block and morphine groups, respectively (P = 0.25). The delay before administration of the first dose of codeine was not statistically different between the two groups: 25 min (5-2,880) vs 21.5 min (5-90), median and range for the block and morphine groups, respectively. The incidence of nausea and vomiting was similar between the two groups.

CONCLUSION

Bilateral superficial cervical plexus block provides transitional analgesia that is clinically equivalent to morphine following remifentanil-based anesthesia in patients undergoing occipital or infratentorial craniotomies.

摘要

背景

本研究比较了瑞芬太尼麻醉后脑干或枕下入路开颅术后双侧颈浅丛阻滞(SCPB)或吗啡用于过渡性镇痛的效果。

方法

本随机对照、双盲研究纳入了 30 例行脑干或枕下入路开颅术的患者,随机分为两组:吗啡组(关颅时静脉给予吗啡 0.1mg·kg⁻¹,术毕行 SCPB,注入 20ml0.9%生理盐水)或阻滞组(关颅时静脉给予吗啡替代物 20ml0.9%生理盐水,术毕行 SCPB,注入 0.5%布比卡因和 2%利多卡因 1:1 混合液 20ml)。术后 1、2、4、8、12、16 和 24 小时,采用 11 点(0-10)数字评分法(NRS)评估术后疼痛。镇痛药物为皮下给予可待因。

结果

研究期间,两组各时间点平均 NRS 评分相似。阻滞组和吗啡组的平均评分(95%置信区间)分别为 3.9(3.4-4.4)和 4.3(3.8-4.9)(P=0.25)。两组首次给予可待因的时间无统计学差异:阻滞组为 25min(5-2,880),吗啡组为 21.5min(5-90)。两组恶心呕吐的发生率相似。

结论

瑞芬太尼麻醉后脑干或枕下入路开颅术后,双侧颈浅丛阻滞可提供与吗啡相当的过渡性镇痛。

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