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Primate testing of TGN1412: right target, wrong cell.
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After TGN1412: recent developments in cytokine release assays.
J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11.
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Evaluation of a TGN1412 analogue using in vitro assays and two immune humanized mouse models.
Toxicol Appl Pharmacol. 2019 Jun 1;372:57-69. doi: 10.1016/j.taap.2019.03.020. Epub 2019 Mar 23.
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CD28 superagonists: what makes the difference in humans?
Immunity. 2008 May;28(5):591-5. doi: 10.1016/j.immuni.2008.04.003.
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Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
PLoS One. 2008 Mar 5;3(3):e1708. doi: 10.1371/journal.pone.0001708.
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Antibody C region influences TGN1412-like functional activity in vitro.
J Immunol. 2012 Dec 15;189(12):5831-40. doi: 10.4049/jimmunol.1201795. Epub 2012 Nov 12.

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The 'cytokine storm': molecular mechanisms and therapeutic prospects.
Trends Immunol. 2021 Aug;42(8):681-705. doi: 10.1016/j.it.2021.06.001. Epub 2021 Jul 1.
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Immune Checkpoints as Therapeutic Targets in Autoimmunity.
Front Immunol. 2018 Oct 8;9:2306. doi: 10.3389/fimmu.2018.02306. eCollection 2018.
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Advanced model systems and tools for basic and translational human immunology.
Genome Med. 2018 Sep 28;10(1):73. doi: 10.1186/s13073-018-0584-8.
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Early implementation of QbD in biopharmaceutical development: a practical example.
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Anti-CD28 Antibody-Initiated Cytokine Storm in Canines.
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The development of therapeutic monoclonal antibodies: overview of the nonclinical safety assessment.
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Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.
PLoS One. 2009;4(2):e4643. doi: 10.1371/journal.pone.0004643. Epub 2009 Feb 27.
4
Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies.
Adv Immunol. 2007;95:111-48. doi: 10.1016/S0065-2776(07)95004-X.
5
Lessons from TGN1412.
Lancet. 2006 Nov 4;368(9547):1569-70; author reply 1570. doi: 10.1016/S0140-6736(06)69651-7.
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Establishing risk of human experimentation with drugs: lessons from TGN1412.
Lancet. 2006 Oct 14;368(9544):1387-91. doi: 10.1016/S0140-6736(06)69562-7.
7
Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.
N Engl J Med. 2006 Sep 7;355(10):1018-28. doi: 10.1056/NEJMoa063842. Epub 2006 Aug 14.
8
Development and homeostasis of T cell memory in rhesus macaque.
J Immunol. 2002 Jan 1;168(1):29-43. doi: 10.4049/jimmunol.168.1.29.

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