房水动力学参数的相关性及其与中央角膜厚度的影响。

Correlations between parameters of aqueous humor dynamics and the influence of central corneal thickness.

机构信息

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.

出版信息

Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):920-6. doi: 10.1167/iovs.10-5494.

DOI:10.1167/iovs.10-5494

PMID:20881287

Abstract

PURPOSE

The individual parameters of aqueous humor dynamics may influence each other to maintain intraocular pressure (IOP) homeostasis. Central corneal thickness (CCT) is known to be associated with onset and progression of glaucoma and can potentially influence the individual parameters of aqueous humor dynamics that maintain IOP. This study investigates the correlation between parameters of aqueous humor dynamics and the influence of CCT in healthy volunteers and compares it with the correlations seen in patients with ocular hypertension.

METHODS

Aqueous humor dynamics (aqueous flow, outflow facility, and uveoscleral outflow), IOP, and pachymetry data from 94 healthy ocular normotensive (ONT) volunteers and 63 ocular hypertensive (OHT) patients was analyzed retrospectively. Linear correlations between individual aqueous humor dynamics parameters and pachymetry were evaluated using scatter plots and the Spearman correlation coefficient where appropriate.

RESULTS

In both groups, a significant (P < 0.05) negative correlation was found between corneal thickness and aqueous flow (ONT, R(2) = 0.14; OHT, R(2) = 0.10) and between corneal thickness and uveoscleral outflow (ONT and OHT, R(2) = 0.10). A significant (P < 0.05) positive correlation was found between aqueous flow and outflow facility (ONT, R (2) = 0.24; OHT, R(2) = 0.10). In healthy controls, but not OHT patients, a significant (P < 0.001) positive correlation was found between aqueous flow and uveoscleral outflow (R(2) = 0.15).

CONCLUSIONS

Thicker corneas may be associated with lower aqueous production and lower uveoscleral outflow. The interplay between parameters of aqueous humor dynamics suggests possible autoregulatory mechanisms in the eye. OHT may differ from ONT subjects in their inability to increase the uveoscleral outflow with increases in aqueous inflow.

摘要

目的

房水动力学的个体参数可能相互影响，以维持眼内压（IOP）的动态平衡。已知中央角膜厚度（CCT）与青光眼的发生和进展有关，并且可能潜在地影响维持 IOP 的房水动力学个体参数。本研究调查了房水动力学参数与健康志愿者 CCT 之间的相关性，并将其与高眼压症患者的相关性进行了比较。

方法

回顾性分析了 94 名健康眼正常压（ONT）志愿者和 63 名高眼压症（OHT）患者的房水动力学（房水流动、流出道通畅性和葡萄膜巩膜流出）、IOP 和角膜厚度数据。使用散点图和 Spearman 相关系数评估了个体房水动力学参数与角膜厚度之间的线性相关性。

结果

在两组中，均发现角膜厚度与房水流动（ONT，R²=0.14；OHT，R²=0.10）和角膜厚度与葡萄膜巩膜流出（ONT 和 OHT，R²=0.10）之间存在显著（P<0.05）的负相关关系。发现房水流动与流出道通畅性之间存在显著（P<0.05）的正相关关系（ONT，R²=0.24；OHT，R²=0.10）。在健康对照组中，但不是在 OHT 患者中，发现房水流动与葡萄膜巩膜流出之间存在显著（P<0.001）的正相关关系（R²=0.15）。