促肾上腺皮质素释放因子信号转导与内脏对应激的反应。
Corticotropin-releasing factor signaling and visceral response to stress.
机构信息
CURE: Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
出版信息
Exp Biol Med (Maywood). 2010 Oct;235(10):1168-78. doi: 10.1258/ebm.2010.009347.
Abstract
Stress may cause behavioral and/or psychiatric manifestations such as anxiety and depression and also impact on the function of different visceral organs, namely the gastrointestinal and cardiovascular systems. During the past years substantial progress has been made in the understanding of the underlying mechanisms recruited by stressors. Activation of the corticotropin-releasing factor (CRF) signaling system is recognized to be involved in a large number of stress-related behavioral and somatic disorders. This review will outline the present knowledge on the distribution of the CRF system (ligands and receptors) expressed in the brain and peripheral viscera and its relevance in stress-induced alterations of gastrointestinal and cardiovascular functions and the therapeutic potential of CRF(1) receptor antagonists.
摘要
压力可能导致行为和/或精神表现，如焦虑和抑郁，也会影响不同内脏器官的功能，即胃肠道和心血管系统。在过去的几年中，人们在理解压力源所涉及的潜在机制方面取得了重大进展。人们认识到，促肾上腺皮质释放因子 (CRF) 信号系统的激活与大量与压力相关的行为和躯体障碍有关。这篇综述将概述 CRF 系统（配体和受体）在大脑和外周内脏中的表达分布及其在压力引起的胃肠道和心血管功能改变中的相关性，以及 CRF(1)受体拮抗剂的治疗潜力。
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