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Inhibition of amphotericin B (Fungizone) toxicity to cells by egg lecithin-glycocholic acid mixed micelles.

作者信息

Brajtburg J, Elberg S, Kobayashi G S, Medoff G

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

Antimicrob Agents Chemother. 1990 Dec;34(12):2415-6. doi: 10.1128/AAC.34.12.2415.

Abstract

Mixed micelles prepared from egg lecithin and the sodium salt of glycocholic acid markedly inhibited amphotericin B toxicity to mammalian cells without significantly affecting the antifungal effects of the drug.

摘要

相似文献

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Inhibition of amphotericin B (Fungizone) toxicity to cells by egg lecithin-glycocholic acid mixed micelles.
Antimicrob Agents Chemother. 1990 Dec;34(12):2415-6. doi: 10.1128/AAC.34.12.2415.

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本文引用的文献

1
Liposomal amphotericin B is toxic to fungal cells but not to mammalian cells.
Biochim Biophys Acta. 1984 Mar 14;770(2):230-4. doi: 10.1016/0005-2736(84)90135-4.
4
Unusual lipid structures selectively reduce the toxicity of amphotericin B.
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6122-6. doi: 10.1073/pnas.85.16.6122.
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Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells.
Biochem Biophys Res Commun. 1988 Aug 15;154(3):954-8. doi: 10.1016/0006-291x(88)90232-x.
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Liposomes prepared dynamically by interactions between bile salt and phospholipid molecules.
Biochim Biophys Acta. 1989 Jun 6;981(2):288-94. doi: 10.1016/0005-2736(89)90039-4.
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Amphotericin B: delivery systems.
Antimicrob Agents Chemother. 1990 Mar;34(3):381-4. doi: 10.1128/AAC.34.3.381.
10
Amphotericin B: current understanding of mechanisms of action.
Antimicrob Agents Chemother. 1990 Feb;34(2):183-8. doi: 10.1128/AAC.34.2.183.

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