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全球分化型甲状腺癌的模式变化。

Global variation in the pattern of differentiated thyroid cancer.

机构信息

University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.

出版信息

Am J Surg. 2010 Oct;200(4):462-6. doi: 10.1016/j.amjsurg.2010.03.009.

DOI:10.1016/j.amjsurg.2010.03.009

PMID:20887838

Abstract

BACKGROUND

The prevalence of differentiated thyroid cancer (DTC) is increasing worldwide. Iodine deficiency is a risk factor for follicular thyroid cancer (FTC). We compared DTC subtypes in an iodine-deficient country with a developed country.

METHODS

A retrospective review of thyroid cancer at tertiary centers in West Africa and the United States. All patients diagnosed with thyroid cancer from 1980 to 2004 were retrieved from the West African Center's Cancer Registry Database. The study period was divided into two groups: 1980 to 1989 and 1990 to 2004. In the American center, a review of patients undergoing surgery for thyroid cancer from 1997 to 2008 was performed.

RESULTS

At the African institution, 322 patients underwent thyroidectomy for cancer from 1980 to 2004. Overall, 31.5% had papillary thyroid cancer (PTC), and 30.3% had FTC. From 1980 to 1989, 27.3% had PTC and 35.8% had FTC. From 1990 to 2004, 35.7% had PTC and 24.8% had FTC. At the American institution, 105 patients underwent surgery for thyroid cancer from 1997 to 2008; 79% had PTC and 7.6% had FTC.

CONCLUSIONS

FTC is still common in developing countries, whereas PTC is the predominant subtype in developed countries. Efforts to decrease iodine deficiency may improve outcomes by changing to a less aggressive subtype.

摘要

背景

全球分化型甲状腺癌（DTC）的发病率正在上升。碘缺乏是滤泡状甲状腺癌（FTC）的一个危险因素。我们比较了一个碘缺乏的发展中国家和一个发达国家的 DTC 亚型。

方法

回顾性分析西非和美国的三级中心的甲状腺癌。从西非癌症登记数据库中检索了 1980 年至 2004 年间所有被诊断为甲状腺癌的患者。研究期间分为两组：1980 年至 1989 年和 1990 年至 2004 年。在美国中心，对 1997 年至 2008 年间因甲状腺癌接受手术的患者进行了回顾性研究。

结果

在非洲机构，322 例患者因癌症接受甲状腺切除术，时间为 1980 年至 2004 年。总体而言，31.5%为乳头状甲状腺癌（PTC），30.3%为 FTC。1980 年至 1989 年，27.3%为 PTC，35.8%为 FTC。1990 年至 2004 年，35.7%为 PTC，24.8%为 FTC。在美国机构，105 例患者因甲状腺癌于 1997 年至 2008 年接受手术；79%为 PTC，7.6%为 FTC。