同种异体干细胞移植受者中多克隆 CD5+ B1a 淋巴细胞增多。
Increased polyclonal CD5+ B1a lymphocytes in a haploidentical stem cell transplant recipient.
机构信息
Department of Pathology and Laboratory Medicine, Chandler Medical Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA.
出版信息
Cytometry B Clin Cytom. 2011 Mar;80(2):119-21. doi: 10.1002/cyto.b.20572. Epub 2010 Oct 1.
BACKGROUND
Atypical lymphocyte populations may be seen in the peritransplant setting. In this case report, we describe an unusually high number of CD5+ B-cells (B1a cells) following transplant.
METHODS
B1a cells identified during routine follow-up by immunophenotypic analysis in a middle-aged man who had a haploidentical stem cell transplant for acute myeloid leukemia were compared with a reference set of post-transplant samples.
RESULTS
Increased but polyclonal B1a cells were identified with 100% donor chimerism.
CONCLUSIONS
Our case demonstrates that a high absolute number of B1a cells may be seen post-transplant and should not be confused with an atypical CD5+ lymphoproliferative disorder. Furthermore, the population of polyclonal CD5+ B lymphocytes from the patient's donor is prominent 7 months post-transplant. This suggests that the maintenance of CD5+ B1 cells prior to conversion to adult-type CD5⁻ B2 cells is not hindered by the recipient adult stromal environment.
背景
移植后可能会出现非典型淋巴细胞群体。在本病例报告中，我们描述了移植后 CD5+B 细胞（B1a 细胞）数量异常增高。
方法
在一名中年男性接受单倍体造血干细胞移植治疗急性髓系白血病的常规随访中，通过免疫表型分析鉴定出 B1a 细胞，并与移植后样本的参考集进行比较。
结果
在 100%供者嵌合的情况下，发现了增多的但为多克隆的 B1a 细胞。
结论
我们的病例表明，移植后可能会出现 B1a 细胞的绝对数量增加，不应与非典型 CD5+淋巴增生性疾病混淆。此外，患者供者的多克隆 CD5+B 淋巴细胞群体在移植后 7 个月时非常明显。这表明在转化为成人型 CD5⁻B2 细胞之前，CD5+B1 细胞的维持不受受者成人基质环境的阻碍。
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