Bendix Laila, Kølvraa Steen
Dansk Center for Aldringsforskning (DARC), Denmark.
Ugeskr Laeger. 2010 Oct 4;172(40):2752-5.
Telomeres are specialized DNA structures, protecting the ends of linear chromosomes. The association between telomeres and cellular aging is well-established, and it has been shown that there is a negative correlation between telomere length and chronological age for many types of human tissue. On the other hand, the association between telomere length and mortality is poor. Nevertheless, it has been suggested that telomeres may play a role in the development of many aging-related diseases. This has led to attempts to develop telomere-elongating treatment.
端粒是特殊的DNA结构,可保护线性染色体的末端。端粒与细胞衰老之间的关联已得到充分证实,并且研究表明,在许多类型的人体组织中,端粒长度与实际年龄之间存在负相关。另一方面,端粒长度与死亡率之间的关联并不显著。尽管如此,有人提出端粒可能在许多与衰老相关疾病的发展中发挥作用。这促使人们尝试开发延长端粒的治疗方法。