[一名被六种抗体免疫的患者的胎儿溶血病：诊断与治疗]
[Fetal hemolytic disease in a patient immunized by six antibodies: diagnosis and treatment].
作者信息
Tantalo V, Rossi E, Gianotti G A, Morotti R, Zuliani G, Buscaglia M, Galligani M
机构信息
Istituti Clinici di Perfezionamento Centro Trasfusionale e di Immunoematologia, Università di Milano.
出版信息
Ann Ostet Ginecol Med Perinat. 1990 Sep-Oct;111(5):321-5.
A case of severe haemolytic disease of the fetus due to six rare alloantibodies is described. In a pregnant women at 23 weeks gestation after the finding of a positive indirect Coombs test maternal antibodies have been precisely identified and titrated: anti-I: 1/23, anti-c: 1/64, anti-S: 1/16, anti-Fya: 1/128, anti-M: 1/64, anti-Jka: 1/32000. Fetal blood group, free and red blood cell adherent antibodies have been investigated on fetal blood samples obtained by means of cord centesis. A compatible donor has been found. Severe fetal anemia has been corrected by ultrasound guided intrauterine transfusions (one abdominal and two intravascular transfusions) with positive outcome of the pregnancy.
本文描述了一例因六种罕见同种抗体导致的严重胎儿溶血病病例。一名妊娠23周的孕妇，间接抗人球蛋白试验呈阳性后，对母体抗体进行了精确鉴定和滴定：抗-I：1/23，抗-c：1/64，抗-S：1/16，抗-Fya：1/128，抗-M：1/64，抗-Jka：1/32000。通过脐静脉穿刺获取胎儿血样，对胎儿血型、游离抗体和红细胞黏附抗体进行了检测。已找到相容供体。通过超声引导下的宫内输血（一次腹腔内输血和两次血管内输血）纠正了严重的胎儿贫血，妊娠结局良好。
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