大鼠中枢α-促黑素细胞激素输注：衰老过程中不同的厌食与代谢变化
Central alpha-MSH infusion in rats: disparate anorexic vs. metabolic changes with aging.
作者信息
Pétervári E, Szabad A O, Soós S, Garami A, Székely M, Balaskó M
机构信息
Department of Pathophysiology and Gerontology, Medical School, University of Pécs, Hungary.
出版信息
Regul Pept. 2011 Jan 17;166(1-3):105-11. doi: 10.1016/j.regpep.2010.10.002. Epub 2010 Oct 8.
UNLABELLED
Changes of the anorexigenic and hypermetabolic components of the overall catabolic effect of alpha-MSH were studied in rats as a function of age. In male Wistar rats a 7 day-long intracerebroventricular infusion of alpha-MSH suppressed food intake and caused a fall in body weight in 2 and 3-4 month-old (young) groups, but it was most effective in the 24 month-old group and had hardly any effect in the 12 month-old (middle-aged) animals. In contrast, metabolic rate as well as biotelemetric measurements of core temperature and heart rate revealed the most pronounced hypermetabolic effects of such infusions at age 12 months. The hypermetabolic effect was still high in the oldest group, but low in the younger groups.
IN CONCLUSION
Changes of the anorexigenic and hypermetabolic effects in the course of aging are not concordant. The overall catabolic activity of alpha-MSH is smallest in the middle-aged and highest in the oldest group.
未标记
研究了α-MSH整体分解代谢作用中食欲抑制和代谢亢进成分随年龄变化的情况，以大鼠作为研究对象。在雄性Wistar大鼠中，连续7天脑室内输注α-MSH可抑制2月龄和3 - 4月龄（年轻）组的食物摄入量并导致体重下降，但在24月龄组中效果最为显著，而在12月龄（中年）动物中几乎没有效果。相比之下，代谢率以及核心体温和心率的生物遥测测量结果显示，在12月龄时这种输注引起的代谢亢进效应最为明显。在最年长的组中，代谢亢进效应仍然较高，但在较年轻的组中较低。
结论
衰老过程中食欲抑制和代谢亢进效应的变化不一致。α-MSH的整体分解代谢活性在中年组最小，在最年长组最高。
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