Servicio de Cirugía, Hospital General Universitario de Elche, Departamento de Patología y Cirugía, Universidad Miguel Hernández, Elche, Alicante, Spain.
Clin Transl Oncol. 2010 Oct;12(10):677-85. doi: 10.1007/s12094-010-0577-6.
The rates of relapse and death remain high in gastric cancer patients, especially in advanced stages. Local relapses in the tumour bed and regional lymph nodes, peritoneal spread as abdominal carcinomatosis, and distant metastasis are common mechanisms of failure after a R0 resection. To overcome this, a multidisciplinary approach has been prompted. In recent years, multidisciplinary treatment has been strengthened by some randomised controlled trials and it is now considered the standard by most groups, although the improvement in long-term survival rates achieved is still limited. This new therapeutic approach in gastric cancer is rapidly evolving and has led to a series of controversies on the best strategy to follow. Some of these controversies are discussed in this paper.
胃癌患者的复发率和死亡率仍然很高,尤其是在晚期。RO 切除术后,肿瘤床和区域淋巴结局部复发、腹膜扩散(腹腔癌转移)和远处转移是常见的失败机制。为了克服这一问题,已经提出了多学科治疗方法。近年来,一些随机对照试验加强了多学科治疗,现在大多数治疗组都认为这是标准治疗方法,尽管长期生存率的提高仍然有限。胃癌的这种新治疗方法正在迅速发展,并引发了一系列关于最佳治疗策略的争议。本文讨论了其中的一些争议。