Section of Rheumatology, Department of Medicine, University of the Philippines - Philippine General Hospital, Manila, Philippines.
Lupus. 2010 Oct;19(12):1365-73. doi: 10.1177/0961203310374305.
In this paper we aim to review the prevalence, incidence and disease presentation of lupus patients in Asian populations. The database of the National Library of Medicine (MEDLINE) through PUBMED up to September 2009 was searched for relevant articles using the search terms 'systemic lupus erythematosus', 'epidemiology', and 'Asia'. Articles on lupus prevalence, incidence, and clinical manifestations were retrieved and their bibliographies further screened for relevant articles. Proceedings of national, regional, and international rheumatology and SLE conferences were likewise searched for relevant abstracts. Retrieval rate of relevant articles was approximately 80%. Prevalence and incidence figures are expressed per 100,000 populations. Among the articles reviewed, epidemiologic information was usually obtained through population surveys or hospital cohorts. Prevalence data are available from 24 countries, and generally fall within 30-50/100,000 population. However, one survey showed a higher prevalence of 70 (Shanghai), while three others showed a lower prevalence of 3.2-19.3 (India, Japan, Saudi Arabia). Only three countries have recorded incidence rates and these varied from 0.9 to 3.1 per annum. Thirty articles from 21 countries describe lupus disease presentation. Common manifestations include mucocutaneous lesions (seen in 52-98% of patients) and arthritis/musculoskeletal complaints (36-95%). Antinuclear antibodies were generally positive in 89-100% of patients, except for two studies. Renal involvement ranged from 18% to 100% with most articles reporting this in >50% of their patients. Discoid lesions, serositis, and neurologic involvement were the least frequently seen symptoms. There is varying epidemiologic information regarding systemic lupus erythematosus among countries in Asia. Prevalence rates usually fall within 30-50/100,000 population. Incidence rates, as reported from three countries, varied from 0.9/100,000 to 3.1% per annum. It is difficult to make generalizations about how the epidemiologic character of the disease varies from country to country. However, similarities in disease manifestations can be observed. .
在本文中，我们旨在回顾亚洲人群中狼疮患者的患病率、发病率和疾病表现。通过 MEDLINE 下的 PUBMED 数据库，使用“系统性红斑狼疮”、“流行病学”和“亚洲”等搜索词，检索了相关文献。检索了有关狼疮患病率、发病率和临床表现的文章，并进一步筛选了这些文章的参考文献，以获取相关文章。还搜索了全国、地区和国际风湿病和系统性红斑狼疮会议的会议记录，以获取相关摘要。检索到的相关文章的检索率约为 80%。患病率和发病率数据以每 10 万人为单位表示。在回顾的文章中，流行病学信息通常通过人群调查或医院队列获得。有 24 个国家提供了患病率数据，通常在 30-50/100,000 人之间。然而，一项调查显示出更高的患病率为 70（上海），而另外三项调查显示出更低的患病率为 3.2-19.3（印度、日本、沙特阿拉伯）。只有三个国家记录了发病率，从 0.9 到 3.1 每年。来自 21 个国家的 30 篇文章描述了狼疮的疾病表现。常见的表现包括粘膜皮肤病变（52-98%的患者可见）和关节炎/肌肉骨骼投诉（36-95%）。除了两项研究外，抗核抗体通常在 89-100%的患者中呈阳性。肾脏受累范围从 18%到 100%，大多数文章报告说，他们的患者中有>50%有这种情况。盘状皮损、浆膜炎和神经病变是最不常见的症状。亚洲各国对系统性红斑狼疮的流行病学信息各不相同。患病率通常在 30-50/100,000 人之间。发病率，如来自三个国家的报告，从 0.9/100,000 到每年 3.1%不等。很难对各国疾病的流行病学特征进行概括。然而，可以观察到疾病表现的相似性。
