在进行双嘧达莫闪烁扫描时，缺血患者和正常受试者的 QRS 初始斜率变化。

Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy with dipyridamole.

机构信息

Department of Internal Medicine, The Lady Davis Carmel Medical Center, 7, Michal Street, Haifa 34362, Israel.

出版信息

Comput Biol Med. 2010 Nov-Dec;40(11-12):869-75. doi: 10.1016/j.compbiomed.2010.09.007. Epub 2010 Oct 15.

DOI:10.1016/j.compbiomed.2010.09.007

PMID:20950799

Abstract

The effect of dipyridamole (Dp) on the linear portion of the first major deflection of the QRS in human electrocardiograms (which we refer to as Fslope) was investigated in the context of myocardial perfusion imaging (MPI), in normal subjects (NS, n=19) and in patients with cardiovascular ischemia (as manifested by a positive MPI scan, n=53). In the majority of participants, Fslope decreased (84% of 19 NS and 77% of 53 patients, p=0.69). The decrease in Fslope was more pronounced in patients with ST-T deviation as compared to those without (32.6±24.5 vs. 22.4±23.1, p=0.24), and in patients vs. NS (24.9±23.5 vs. 19.6±23.4, p=0.44). A change in Fslope is a sensitive (but not specific) measure for detecting the effect of Dp on the myocardium in the setting of scintigraphy.

摘要

在心肌灌注成像（MPI）的背景下，我们研究了双嘧达莫（Dp）对人体心电图中 QRS 波群第一个主要偏转的线性部分（我们称之为 Fslope）的影响，研究对象包括正常受试者（NS，n=19）和心血管缺血患者（MPI 扫描阳性，n=53）。在大多数参与者中，Fslope 降低（19 名 NS 中的 84%和 53 名患者中的 77%，p=0.69）。与没有 ST-T 偏移的患者相比，有 ST-T 偏移的患者 Fslope 的降低更为明显（32.6±24.5 与 22.4±23.1，p=0.24），与 NS 相比，患者的 Fslope 降低更为明显（24.9±23.5 与 19.6±23.4，p=0.44）。Fslope 的变化是一种敏感（但非特异性）的方法，可以检测在闪烁成像中 Dp 对心肌的作用。