Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 760 Biomedical Research Tower, 460 W 12th Avenue, Columbus, OH 43210-1239, United States.
J Neuroimmunol. 2011 Jan;230(1-2):105-13. doi: 10.1016/j.jneuroim.2010.09.010. Epub 2010 Oct 14.
Multiple sclerosis (MS) is a demyelinating disease of the CNS involving T cell targeting of myelin antigens. During pregnancy, women with MS experience decreased relapses followed by a post partum disease flare. Using murine experimental autoimmune encephalomyelitis, we recapitulate pregnancy findings in both relapsing and progressive models. Pregnant mice produced less TNF-α, IL-17 and exhibited reduced CNS pathology relative to non-pregnant controls. Microparticles, called exosomes, shed into the blood during pregnancy were isolated and found to significantly suppress T cell activation relative to those from non-pregnant controls. These results demonstrate the immunosuppressive potential of pregnancy and serum-derived pregnancy exosomes.
多发性硬化症（MS）是一种中枢神经系统脱髓鞘疾病，涉及 T 细胞针对髓鞘抗原的靶向作用。在怀孕期间，患有 MS 的女性经历疾病发作减少，随后出现产后疾病发作。使用实验性自身免疫性脑脊髓炎的小鼠模型，我们重现了复发型和进展型模型中的妊娠发现。与非妊娠对照组相比，妊娠小鼠产生的 TNF-α、IL-17 减少，中枢神经系统病理学减轻。在怀孕期间释放到血液中的称为外泌体的微粒被分离出来，并发现与非妊娠对照组相比，它们能显著抑制 T 细胞的激活。这些结果表明妊娠和血清来源的妊娠外泌体具有免疫抑制潜力。
