成功利用母体血液治疗因抗Kp(b)所致的胎儿及新生儿严重溶血病。
Successful use of maternal blood in the management of severe hemolytic disease of the fetus and newborn due to anti-Kp(b).
作者信息
Bleile Michelle J, Rijhsinghani Asha, Dwyre Denis M, Raife Thomas J
机构信息
Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States.
Department of Obstetrics and Gynecology, Roy J. and Lucille A. Carver College of Medicine, and University of Iowa, Iowa City, IA 52242, United States.
出版信息
Transfus Apher Sci. 2010 Dec;43(3):281-283. doi: 10.1016/j.transci.2010.09.010. Epub 2010 Oct 15.
BACKGROUND
The incidence of hemolytic disease of the fetus and newborn (HDFN) has decreased since the introduction of Rh immunoglobulin prophylaxis in Rh(D)-negative pregnant women. Thus, the relative incidence of rare alloantibody-related HDFN has increased. The lack of available maternally matched red blood cells for transfusion in these cases may create management difficulties.
CASE
We report a case of anti-Kp(b) HDFN. Severe fetal anemia required intrauterine transfusion. Difficulty in obtaining Kp(b)-negative blood necessitated using the mother's donated RBCs.
CONCLUSION
Severe HDFN with rare antibodies can be managed successfully using maternal blood.
背景
自对Rh(D)阴性孕妇采用Rh免疫球蛋白预防措施以来，胎儿及新生儿溶血病（HDFN）的发病率有所下降。因此，罕见同种抗体相关HDFN的相对发病率有所上升。在这些病例中，缺乏可供输血的与母亲血型匹配的红细胞可能会给治疗带来困难。
病例
我们报告一例抗Kp(b) HDFN病例。严重的胎儿贫血需要进行宫内输血。由于难以获得Kp(b)阴性血液，不得不使用母亲捐献的红细胞。
结论
使用母亲的血液可以成功治疗罕见抗体所致的严重HDFN。
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