Laboratory Animal Center, Department of Surgery, Chang Gung Memorial Hospital at Linko, Chang Gung University, No. 5, Fu-Shing Street, Guei-Shan Shiang, 333, Tao-Yuan, Taiwan, ROC.
Surg Endosc. 2011 May;25(5):1652-8. doi: 10.1007/s00464-010-1401-7. Epub 2010 Oct 17.
The aim of this study was to evaluate the performance of a novel transtracheal endoscopic technique for thoracic evaluation and intervention in a large animal model.
In 12 animals (6 pigs and 6 dogs) under general anesthesia, a tracheal incision was made on the right lateral wall of the lower trachea and used as an entrance for thoracic evaluation and intervention. Postoperative follow-up included endoscopy at 1 and 2 weeks after surgery and necropsy at 2 weeks after surgery.
Transtracheal opening and thoracic exploration were achieved in all animals. Four animals (3 pigs and 1 dog) died as a result of complications from the procedure. At the follow-up endoscopy, healing at the tracheal opening region was noted in seven animals.
The transtracheal approach to the thoracic cavity is technically feasible in both porcine and canine models (4/12 animals died). The canine model is perhaps more suitable than the porcine model for the study of the transtracheal approach to the thoracic cavity.
本研究旨在评估一种新的经气管内镜技术在大型动物模型中进行胸部评估和介入的性能。
在 12 只动物(6 只猪和 6 只狗)全身麻醉下,在下气管的右侧壁做一个气管切口,作为胸部评估和介入的入口。术后随访包括手术后 1 周和 2 周的内镜检查和手术后 2 周的尸检。
所有动物均成功进行经气管开口和胸部探查。4 只动物(3 只猪和 1 只狗)因手术并发症死亡。在后续的内镜检查中,7 只动物的气管开口区域有愈合迹象。
经气管入路进入胸腔在猪和犬模型中都是可行的(12 只动物中有 4 只死亡)。犬模型可能比猪模型更适合研究经气管入路进入胸腔。