粪便潜血试剂盒在健康建筑工人队列结直肠癌筛查项目中的比较研究。

A comparative study of faecal occult blood kits in a colorectal cancer screening program in a cohort of healthy construction workers.

机构信息

Department of Gastroenterology/Clinical Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.

出版信息

Ir J Med Sci. 2011 Mar;180(1):103-8. doi: 10.1007/s11845-010-0605-0. Epub 2010 Oct 17.

DOI:10.1007/s11845-010-0605-0

PMID:20953981

Abstract

BACKGROUND

The incidence of colorectal cancer (CRC) has been increasing. We evaluated uptake rates and outcomes of faecal immunochemical test (FIT) and Guaiac test (gFOBT) kits as part of a two-step CRC screening.

METHODS

A 3-year CRC screening program for a defined population of construction workers was conducted. Those satisfying the inclusion criteria were provided with gFOBT or FIT kits. Individuals testing positive were invited for a colonoscopy.

RESULTS

A total of 909 faecal testing kits were distributed. Age range was 53-60 years. Compliance rate was higher for FIT (58.3%) as compared to gFOBT (46.7%) (p = 0.0006). FIT detected adenomatous polyps and CRC in 37.5 and 25%, respectively, whereas; gFOBT detected 23.5 and 18%. Colonoscopies were normal in 53 and 25% tested positive by gFOBT and FIT, respectively (p = 0.016).

CONCLUSION

The FIT was more cost-effective when compared with gFOBT with higher return rate, sensitivity and specificity. A comparative study of faecal occult blood kits in a CRC screening program in a healthy cohort of construction workers.

摘要

背景

结直肠癌（CRC）的发病率一直在上升。我们评估了粪便免疫化学检测（FIT）和愈创木脂粪便潜血检测（gFOBT）试剂盒作为两步法 CRC 筛查的应用率和结果。

方法

对一个特定建筑工人人群进行了为期 3 年的 CRC 筛查计划。符合纳入标准的人提供了 gFOBT 或 FIT 试剂盒。检测阳性的个体被邀请进行结肠镜检查。

结果

共发放了 909 份粪便检测试剂盒。年龄范围为 53-60 岁。与 gFOBT（46.7%）相比，FIT（58.3%）的依从率更高（p=0.0006）。FIT 分别检测到 37.5%和 25%的腺瘤性息肉和 CRC，而 gFOBT 分别检测到 23.5%和 18%。gFOBT 和 FIT 检测阳性的个体中，结肠镜检查正常的分别为 53%和 25%（p=0.016）。