导管原位癌术后全身治疗的影响
The impact of systemic therapy following ductal carcinoma in situ.
作者信息
Eng-Wong Jennifer, Costantino Joseph P, Swain Sandra M
机构信息
Department of Internal Medicine, Division of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC, USA.
出版信息
J Natl Cancer Inst Monogr. 2010;2010(41):200-3. doi: 10.1093/jncimonographs/lgq021.
Abstract
Following local therapy for ductal carcinoma in situ (DCIS), tamoxifen reduces the risk of ipsilateral and contralateral breast cancer by 30%-50%. Studies of tamoxifen in women with resected DCIS have not shown any effect on overall or cancer-specific survival. The adverse event profile of tamoxifen is well characterized, and individual risks and benefits should be assessed to guide decision making. We review the results of the phase III trials of tamoxifen in DCIS as well as the emerging risk reduction therapies.
摘要
对于导管原位癌（DCIS）进行局部治疗后，他莫昔芬可将同侧和对侧乳腺癌的风险降低30%-50%。对接受DCIS切除术的女性使用他莫昔芬的研究未显示对总生存率或癌症特异性生存率有任何影响。他莫昔芬的不良事件特征已得到充分描述，应评估个体的风险和益处以指导决策。我们回顾了他莫昔芬治疗DCIS的III期试验结果以及新出现的风险降低疗法。
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本文引用的文献
1
Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women.低剂量他莫昔芬与非诺贝特预防高危绝经前女性乳腺癌的随机双盲2×2试验。
J Clin Oncol. 2009 Aug 10;27(23):3749-56. doi: 10.1200/JCO.2008.19.3797. Epub 2009 Jul 13.
2
The National Cancer Institute of Canada Clinical Trials Group MAP.3 trial: an international breast cancer prevention trial.加拿大国家癌症研究所临床试验组 MAP.3 试验：一项国际乳腺癌预防试验。
Curr Oncol. 2007 Jun;14(3):89-96. doi: 10.3747/co.2007.117.
3
Tamoxifen for the prevention of breast cancer: current status of the National Surgical Adjuvant Breast and Bowel Project P-1 study.他莫昔芬用于预防乳腺癌：国家外科辅助乳腺和肠道项目P-1研究的现状
J Natl Cancer Inst. 2005 Nov 16;97(22):1652-62. doi: 10.1093/jnci/dji372.
4
Aromatase inhibitors for breast cancer prevention.用于预防乳腺癌的芳香化酶抑制剂
J Clin Oncol. 2005 Mar 10;23(8):1636-43. doi: 10.1200/JCO.2005.11.027.
5
Neoadjuvant hormonal therapy for ductal carcinoma in situ: trial design and preliminary results.导管原位癌的新辅助激素治疗：试验设计与初步结果
Ann Surg Oncol. 2004 Jan;11(1 Suppl):37S-43S. doi: 10.1007/BF02524794.
6
A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer.他莫昔芬治疗两至三年后依西美坦用于绝经后原发性乳腺癌女性的一项随机试验。
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