睾酮是 2 型糖尿病男性骨密度的独立决定因素。

Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus.

机构信息

Department of Public Health, Gomel State Medical University, Gomel, Belarus.

出版信息

Clin Chem Lab Med. 2011 Jan;49(1):99-103. doi: 10.1515/CCLM.2011.016. Epub 2010 Oct 20.

DOI:10.1515/CCLM.2011.016

PMID:20961190

Abstract

BACKGROUND

Although many reports have elucidated pathophysiological characteristics of abnormal bone metabolism in patients with type 2 diabetes mellitus (DT2), determinants of bone mineral density (BMD) in patients with DT2 are still controversial.

METHODS

We examined 168 Belarussian men 45-60 years of age. Plasma total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, hemoglobin A(1c) (HbA(1c)), immunoreactive insulin, and C-reactive protein concentrations were assessed. BMD was measured using dual energy X-ray densitometry of the lumbar spine (L(1)-L(4)). Total testosterone (TT) and sex hormone-binding globulin were measured, and free testosterone (FT) was calculated.

RESULTS

Using univariate linear regression analysis, BMD of the lumbar spine was significantly correlated with FT (r=0.32, p<0.01) and TT (r=0.36, p<0.01). Using multiple linear regression analysis adjusted for confounding factors, BMD was significantly correlated with TT (β=0.23, p<0.001) and TC (β=-0.029, p=0.005). Age (β=0.005, p=0.071), body mass index (β=0.005, p=0.053), HbA(1c) (β=-0.002, p=0.72) and duration of diabetes (β=0.001, p=0.62) were not significantly correlated with BMD.

CONCLUSIONS

Our data indicate that androgens are independent determinants of BMD in male patients with DT2.

摘要

背景

尽管许多报告已经阐明了 2 型糖尿病（DT2）患者异常骨代谢的病理生理特征，但 DT2 患者骨密度（BMD）的决定因素仍存在争议。

方法

我们检查了 168 名 45-60 岁的白俄罗斯男性。评估了血浆总胆固醇（TC）、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、甘油三酯、糖化血红蛋白 A1c（HbA1c）、免疫反应性胰岛素和 C 反应蛋白浓度。使用腰椎（L1-L4）的双能 X 射线吸收法测量 BMD。测量了总睾酮（TT）和性激素结合球蛋白，并计算了游离睾酮（FT）。

结果

使用单变量线性回归分析，腰椎 BMD 与 FT（r=0.32，p<0.01）和 TT（r=0.36，p<0.01）呈显著相关。使用多元线性回归分析调整混杂因素后，BMD 与 TT（β=0.23，p<0.001）和 TC（β=-0.029，p=0.005）呈显著相关。年龄（β=0.005，p=0.071）、体重指数（β=0.005，p=0.053）、HbA1c（β=-0.002，p=0.72）和糖尿病病程（β=0.001，p=0.62）与 BMD 无显著相关性。