Department of Dermatology and STD, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
Dermatol Surg. 2010 Nov;36(11):1711-7. doi: 10.1111/j.1524-4725.2010.01723.x.
Therapeutic interventions for microcystic lymphatic malformation (MLM), including surgical resection, have historically been difficult and frustrating because of a high recurrence rate due to multifocal lesions and failure to address the deeper component and excessive morbidity associated with excision of extensive lesions.
This study represents a retrospective analysis of response to treatment of 14 consecutive patients with MLM. The first four patients were treated with sclerotherapy alone using 3% polidocanol. The next 10 patients were treated with the combination technique of radiofrequency ablation (RFA) and sclerotherapy. The sessions were repeated at monthly intervals until complete clearance.
Nine of 10 patients who were treated with the combination technique achieved near-complete clearance. There were minimal intra- and postoperative sequelae. The patients treated with the combination technique also achieved faster results.
RFA ablates the lesions and achieves hemostasis while the sclerosant injected in and around the lesion reaches the deeper vascular lesions, preventing recurrence. The minimally invasive combination technique of RFA with sclerotherapy is a modality that can be used in the treatment of extensive microcystic malformations where surgical excision would lead to extensive scarring.
微囊性淋巴管畸形(MLM)的治疗干预措施,包括手术切除,由于多灶性病变导致复发率高,且无法解决深部病变和广泛切除引起的过度发病率,因此一直具有挑战性和令人沮丧。
本研究代表了对 14 例 MLM 患者治疗反应的回顾性分析。前 4 例患者单独使用 3%聚多卡醇行硬化治疗。接下来的 10 例患者接受射频消融(RFA)和硬化治疗联合技术治疗。每月重复治疗直至完全清除。
接受联合技术治疗的 10 例患者中有 9 例接近完全清除。术中及术后后遗症极小。接受联合技术治疗的患者也更快地获得了结果。
RFA 消融病变并止血,同时注入病变内和周围的硬化剂到达深部血管病变,防止复发。RFA 联合硬化治疗的微创联合技术是一种可以用于治疗广泛微囊性畸形的方法,手术切除会导致广泛的瘢痕形成。