亲环素 A：心血管治疗的有前途的新靶点。
Cyclophilin A: promising new target in cardiovascular therapy.
机构信息
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry.
出版信息
Circ J. 2010 Nov;74(11):2249-56. doi: 10.1253/circj.cj-10-0904. Epub 2010 Oct 15.
Abstract
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.
摘要
亲环蛋白 A（CyPA）已被研究为一种多功能蛋白，在多种炎症条件下上调，如类风湿性关节炎、自身免疫性疾病和癌症。CyPA 被归类为免疫亲和素，具有多种细胞内功能，包括细胞内信号转导、蛋白质运输和其他蛋白质活性的调节。除了其细胞内功能外，CyPA 还是一种分泌分子，在心血管疾病中具有生理和病理作用，使其成为心血管疾病如血管狭窄、动脉粥样硬化和腹主动脉瘤的潜在生物标志物和介质。
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