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[卡波西肉瘤并发重度哮喘长期皮质激素治疗]

[Kaposi's sarcoma complicating long-term corticotherapy for severe asthma].

作者信息

Bruet A, Mahe A, Sei J F, Mathe C, Felsenheld C, Lechevalier L, Fendler J P

机构信息

Service de Médecine Interne-Néphrologie, C.H.U. Poissy.

出版信息

Rev Med Interne. 1990 Jul-Aug;11(4):322-4. doi: 10.1016/s0248-8663(05)80867-7.

Abstract

Kaposi's sarcoma frequently develops in patients with immune deficiency which may be drug-induced (corticosteroids, immunodepressants). We report a case of Kaposi's sarcoma in a 75-year old man who had been taking oral prednisone continually for 7 years as treatment of severe asthma. Data from the literature clearly show that corticosteroid therapy may trigger the development of Kaposi's sarcoma in patients who usually possess several other pathogenetic factors of that disease, such as pre-existing immune deficiency, environmental (viruses) or genetic factors. In some cases, withdrawing corticosteroids may result in complete remission of the cutaneous lesions.

摘要

卡波西肉瘤常见于免疫缺陷患者,免疫缺陷可能由药物引起(如皮质类固醇、免疫抑制剂)。我们报告一例75岁男性卡波西肉瘤病例,该患者因严重哮喘持续口服泼尼松7年。文献数据清楚表明,皮质类固醇治疗可能会在通常具备该疾病其他几种致病因素(如既往存在的免疫缺陷、环境因素(病毒)或遗传因素)的患者中引发卡波西肉瘤。在某些情况下,停用皮质类固醇可能会导致皮肤病变完全缓解。

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