Pérez-Valdivia M A, Ramos M Toro, Gentil M A, Osuna A, Mazuelos A, Sola E, Rodríguez-Benot A
Transplant Coordination Center, Andalusian Health Service, Seville, Spain.
Transplant Proc. 2010 Oct;42(8):3128-9. doi: 10.1016/j.transproceed.2010.05.124.
Renal transplantation is the best therapeutic choice in patients with end-stage renal disease (ESRD), with donation from living donors the alternative that offers the best medium- and long-term results. Because of the limited number of cadaver donors and the progressive increase in donor age, transplantation from living donors has become the renal replacement treatment of choice. Several studies have demonstrated that donation does not increase the donor's risk of developing ESRD in the long term. Some studies have asserted that a donor's life expectancy increases as a result of the comprehensive study and screening process they must undergo. The objective of the present study was to evaluate the vital status and onset of chronic renal disease in 101 living kidney donors in Andalusia, Spain, during 2006-2009, based on data obtained from the Sistema de Información de la Coordinación Autonómica de Trasplantes de Andalucía (Regional Transplants Coordination of Andalusia). Donor survival was 99%, and the only death, from lung cancer, was not associated with the surgical procedure. Only 5 transplants failed during this period, and no donors developed ESRD. Neither the probability of survival nor the risk of developing ESRD in donors was influenced by kidney donation.
肾移植是终末期肾病(ESRD)患者的最佳治疗选择,活体供肾移植是能提供最佳中长期效果的替代方案。由于尸体供体数量有限且供体年龄逐渐增加,活体供肾移植已成为首选的肾脏替代治疗方法。多项研究表明,从长期来看,捐献并不会增加供体患终末期肾病的风险。一些研究称,由于供体必须接受全面的检查和筛查过程,其预期寿命会增加。本研究的目的是基于从安达卢西亚地区移植协调信息系统(Sistema de Información de la Coordinación Autonómica de Trasplantes de Andalucía)获得的数据,评估2006年至2009年期间西班牙安达卢西亚101名活体肾供体的生命状态和慢性肾病的发病情况。供体存活率为99%,唯一的死亡病例死于肺癌,与手术无关。在此期间只有5例移植失败,没有供体发展为终末期肾病。供体的存活概率和患终末期肾病的风险均不受肾脏捐献的影响。