Nihoul-Fekete C
Service de Chirurgie, Hôpital des Enfants-Malades, Paris.
Chirurgie. 1990;116(6-7):529-34; discussion 534-6.
Therapeutic operations on fetuses have been attempted for the first time in the 60's. The major problem for obstetricians at that time was the Rh incompatibility, and Lilley performed the first successful intraperitoneal intrauterine fetal blood transfusion in 1963. Since then the attempts have become increasingly numerous, and experiments in animals proved their feasibility and surgical safety both for the mother and for the fetus. The possible advantages of fetal surgery are not readily assessed, and the indications for fetal surgery can currently be justified only if the natural history of the malformation is known, the physiopathology of the affected organ studied, and the correction of the anatomical abnormality proved to produce the resumption of organ development. The surgical indications should be discussed with practitioners not involved in the program, with the informed consent of the parents, and all the results, whatever they be, should be communicated to the medical community.
对胎儿进行治疗性手术的尝试始于20世纪60年代。当时产科医生面临的主要问题是Rh血型不合,1963年利利成功实施了首例腹腔内宫内胎儿输血。从那时起,此类尝试越来越多,动物实验证明了其对母亲和胎儿的可行性及手术安全性。胎儿手术的潜在优势难以轻易评估,目前只有在了解畸形的自然病史、研究受累器官的生理病理学,且证明解剖异常的矫正能使器官恢复发育时,胎儿手术的指征才具有合理性。手术指征应与未参与该项目的从业者进行讨论,并获得父母的知情同意,所有结果无论如何都应告知医学界。