Wananukul Winai, Klaikleun Supranee, Sriapha Charuwan, Tongpoo Achara
Department of Medicine, Ramathibodi Poison Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2010 Oct;93(10):1145-9.
Activated charcoal (AC) is recommended for treatment of acute poisoning, thereby decreasing gastrointestinal tract absorption. AC from different sources may have different adsorptive capacity. The AC that is available in Thailand has not been proven yet for its efficacy The authors simulated paracetamol overdose model for the present study.
To assess the efficacy of AC that is available in Thailand in decreasing absorption of paracetamol at supratherapeutic dose.
This was a two-arm, prospective, crossover study. Washout period was 1 week Twelve healthy male volunteers participated. All volunteers were randomly assigned to either sequence of control-experiment (CE) or EC. The participants ingested 60 mg/Kg of paracetamol at Time=0. At Time = 0.25 hour, they ingested 50 g of AC as slurry with 250 ml of water when they were assigned as E, but drank 250 mL of water when were assigned as C. Blood samples were serially collected for determination of paracetamol concentration and calculating pharmacokinetic parameters, area under the time-concentration curve (AUC (0, infinity)).
Means of the AUC (0, infinity) were 313.7 +/- 29.8 and 184.8 +/- 91.6 mg-h/ L in the control and experimental arm, respectively It was statistically different (p = 0.01).
The tested AC was found to be able to reduce the absorption of the supratherapeutic dose of paracetamol.
活性炭（AC）被推荐用于治疗急性中毒，从而减少胃肠道吸收。不同来源的活性炭可能具有不同的吸附能力。泰国现有的活性炭其疗效尚未得到证实。作者为本研究模拟了对乙酰氨基酚过量模型。
评估泰国现有的活性炭在减少超治疗剂量对乙酰氨基酚吸收方面的疗效。
这是一项双臂、前瞻性、交叉研究。洗脱期为1周。12名健康男性志愿者参与。所有志愿者被随机分配到对照-实验（CE）或实验-对照（EC）序列。参与者在时间=0时摄入60mg/kg的对乙酰氨基酚。在时间=0.25小时时，当他们被分配为E组时，以含250ml水的混悬液形式摄入50g活性炭，但当被分配为C组时饮用250ml水。连续采集血样以测定对乙酰氨基酚浓度并计算药代动力学参数，即时间-浓度曲线下面积（AUC(0,∞)）。
对照臂和实验臂的AUC(0,∞)均值分别为313.7±29.8和184.8±91.6mg·h/L，差异有统计学意义（p = 0.01）。
经测试的活性炭能够减少超治疗剂量对乙酰氨基酚的吸收。
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