Lundeen Elizabeth, Schueth Tobias, Toktobaev Nurjan, Zlotkin Stanley, Hyder S M Ziauddin, Houser Robert
Kyrgyz-Swiss-Swedish Health Project, Bishkek, Kyrgyz Republic.
Food Nutr Bull. 2010 Sep;31(3):446-60. doi: 10.1177/156482651003100307.
Iron-deficiency anemia is widespread among young children in the Kyrgyz Republic, and there is an urgent need to identify an effective intervention to address this significant public health problem.
To test the effectiveness of a 2-month intervention with daily home fortification of complementary food using micronutrient powder (Sprinkles) in reducing anemia among children 6 to 36 months of age in the Kyrgyz Republic.
In this cluster-randomized, community-based effectiveness trial conducted in three regions of the Kyrgyz Republic, 24 clusters of children aged 6 to 36 months were randomly assigned to two groups. The intervention group (12 clusters, n = 1,103) received 60 sachets of micronutrient powder (12.5 mg elemental iron), which were taken as one sachet daily for 2 months. The control group (12 clusters, n = 1,090) did not receive micronutrient powder until after the study period. Blood hemoglobin concentration was assessed at the start and end of the intervention.
From baseline to follow-up, the mean hemoglobin concentration in the intervention group increased by 7 g/L, whereas it decreased by 2 g/L in the control group (p < .001). The prevalence of anemia (hemoglobin < 110 g/L) in the intervention group decreased from 72% at baseline to 52% at follow-up, whereas it increased from 72% to 75% in the control group (p < .001). Compliance with the intervention was high, with children consuming on average 45 of the 60 sachets given.
A course of 60 Sprinkles micronutrient powder sachets taken daily for 2 months is effective in improving hemoglobin levels and reducing the prevalence of anemia among young children in the Kyrgyz Republic.
缺铁性贫血在吉尔吉斯共和国的幼儿中广泛存在，迫切需要确定一种有效的干预措施来解决这一重大公共卫生问题。
测试为期2个月的使用微量营养素粉（“撒剂”）对辅食进行每日家庭强化的干预措施在降低吉尔吉斯共和国6至36个月龄儿童贫血方面的有效性。
在吉尔吉斯共和国三个地区进行的这项整群随机、基于社区的有效性试验中，将24个6至36个月龄儿童的群组随机分为两组。干预组（12个群组，n = 1103）接受60包微量营养素粉（12.5毫克元素铁），每天服用1包，持续2个月。对照组（12个群组，n = 1090）在研究期结束后才接受微量营养素粉。在干预开始和结束时评估血液血红蛋白浓度。
从基线到随访，干预组的平均血红蛋白浓度增加了7 g/L，而对照组则下降了2 g/L（p < .001）。干预组贫血（血红蛋白<110 g/L）患病率从基线时的72%降至随访时的52%，而对照组则从72%升至75%（p < .001）。干预的依从性很高，儿童平均食用了所给60包中的45包。
连续2个月每天服用60包“撒剂”微量营养素粉可有效提高吉尔吉斯共和国幼儿的血红蛋白水平并降低贫血患病率。
