理论研究鲁比考迪福林级联。

Theoretical investigation of the rubicordifolin cascade.

机构信息

Department of Chemistry, University of California, Berkeley, California 94720, United States.

出版信息

Org Lett. 2010 Nov 19;12(22):5162-5. doi: 10.1021/ol102157d. Epub 2010 Oct 25.

PMID:20973524

Abstract

The results of a theoretical investigation on the complex cascade reaction leading to the natural product rubicordifolin are reported. These computations analyze the discrete transformations that are required during the conversion of the vinyl naphthoquinone starting material into the natural product, including two pseudopericyclic cyclizations as well as a diastereoselective, hetero-Diels-Alder reaction.

摘要

报道了关于导致天然产物红古豆醇的复杂级联反应的理论研究结果。这些计算分析了在将乙烯基萘醌起始原料转化为天然产物过程中所需的离散转化，包括两个拟周环环化以及立体选择性的杂-Diels-Alder 反应。