Secco G B, Fardelli R, Lapertosa G, Fulcheri E, Rovida S, Ratto G B, Prior C
Istituto di Patologia Chirurgica, Università di Genova.
Minerva Chir. 1990 Nov;45(21-22):1347-53.
Histological material from 121 patients who underwent surgery for cancer of the left colon and rectum was reexamined by two pathologists according to criteria put forward in Jass' histopathological classification. A prevalence of Jass' grades II (36.4%) and III (47.9%) were observed in this series. There was no correlation between the site of neoplasia but there was a clearly increased incidence of advanced stages C and D according to Dukes-Kirklin's classification within Jass' grades II, III and IV (p less than 0.005) and growth pattern, but not for the configuration of tubules. The new histopathological model proved to be more reliable in prognostic terms in the case of cancer of the rectum compared to that of the left colon, but at present its clinical significance is limited to specifying the site and stage of the neoplasia. The latter was found to be the most reliable prognostic parameter.
121例接受左半结肠和直肠癌手术的患者的组织学材料,由两位病理学家根据贾斯组织病理学分类提出的标准重新进行检查。在该系列中观察到贾斯二级(36.4%)和三级(47.9%)的患病率。肿瘤部位之间没有相关性,但根据杜克斯-柯克林分类,在贾斯二级、三级和四级中,C期和D期晚期的发病率明显增加(p小于0.005),与生长模式有关,但与小管结构无关。与左半结肠癌相比,新的组织病理学模型在直肠癌病例的预后方面被证明更可靠,但目前其临床意义仅限于确定肿瘤的部位和分期。发现后者是最可靠的预后参数。