鼓室内类固醇治疗中重度至极重度突发性感音神经性听力损失的补救治疗。

Intratympanic steroids in severe to profound sudden sensorineural hearing loss as salvage treatment.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.

出版信息

Clin Exp Otorhinolaryngol. 2010 Sep;3(3):122-5. doi: 10.3342/ceo.2010.3.3.122. Epub 2010 Sep 17.

DOI:10.3342/ceo.2010.3.3.122

PMID:20978628

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2958501/

Abstract

OBJECTIVES

Intratympanic steroids are being increasingly used in the treatment of sudden sensorineural hearing loss (SSNHL) after the failure of systemic therapy. This study evaluated the efficacy of administering intratympanic dexamethasone (ITD) as a salvage treatment for severe to profound SSNHL.

METHODS

We reviewed the medical records of patients who presented with severe to profound SSNHL between January 2007 and December 2009. ITD was given about 14 days after the initial systemic treatment. Successful recovery was defined as complete or partial recovery using Sigel's criteria. We compared the results of treatment between the severe SSNHL (S-SSNHL) and profound SSNHL (P-SSNHL) groups.

RESULTS

All the patients in the S-SSNHL group showed significant improvement, as compared to the P-SSNHL group (P=0.017). The recovery rate after the initial systemic treatment was 36% (9/25) in the S-SSNHL group and 18.1% (4/22) in the P-SSNHL group (P=0.207). In comparison, the recovery rate of ITD as a salvage treatment was 37.5% (6/16) in the S-SSNHL group and 5.5% (1/18) in the P-SSNHL group (P=0.03).

CONCLUSION

Our comparative study dose not support the efficacy of ITD as salvage treatment for patients with P-SSNHL as compared with that for S-SSNHL. We recommend that patients with P-SSNHL be informed about the low efficacy of ITD as a salvage treatment.

摘要

目的

全身治疗失败后，鼓室内给予类固醇治疗突发性聋（SSNHL）越来越受到关注。本研究评估了鼓室内给予地塞米松（ITD）作为严重至极重度 SSNHL 挽救治疗的疗效。

方法

我们回顾了 2007 年 1 月至 2009 年 12 月期间因严重至极重度 SSNHL 就诊的患者的病历资料。初始全身治疗后约 14 天给予 ITD。根据 Sigel 的标准，完全或部分恢复定义为成功恢复。我们比较了严重 SSNHL（S-SSNHL）和极重度 SSNHL（P-SSNHL）两组的治疗结果。

结果

与 P-SSNHL 组相比，所有 S-SSNHL 组患者均有显著改善（P=0.017）。S-SSNHL 组初始全身治疗后的恢复率为 36%（9/25），P-SSNHL 组为 18.1%（4/22）（P=0.207）。相比之下，S-SSNHL 组 ITD 挽救治疗的恢复率为 37.5%（6/16），P-SSNHL 组为 5.5%（1/18）（P=0.03）。