Suppr超能文献

保留下颌骨的经口拉出式口咽切除术治疗晚期口咽癌:一项前瞻性研究

Mandible preserving pull-through oropharyngectomy for advanced oropharyngeal cancer: a pilot study.

作者信息

Masuda Muneyuki, Fukushima Junichi, Kadota Hideki, Kamizono Kenichi, Ejima Masayoshi, Taura Masahiko

机构信息

Department of Otorhinolaryngology and Head and Neck Surgery, Kyushu Koseinenkin Hospital, 1-8-1 Kishinoura, Nishiku, Kitakyushu, Japan.

出版信息

Auris Nasus Larynx. 2011 Jun;38(3):392-7. doi: 10.1016/j.anl.2010.08.010. Epub 2010 Oct 25.

Abstract

OBJECTIVE

Through our experiences in the parapharyngeal space (PPS) surgery, we have learned that it is possible to gain wide exposure of the PPS near to the skull base with a transcervical approach alone. Thus, we presumed that if this type of transcervical approach would be combined with a transoral approach, a less invasive oropharyngectomy without mandibulotomy and lip-splitting might be feasible for the resection of advanced oropharyngeal cancer, sparing the morbidities associated with conventional mandibular swing approach or its modified procedures. We termed this method as a mandible preserving pull-through oropharyngectomy (MPPO) and evaluated its feasibility and efficacy in this pilot study.

MATERIALS AND METHODS

MPPO was applied for a series of 7 patients with advanced lateral and/or upper oropharyngeal cancer including 2 patients with T4 stage. Our current application of MPPO excludes tumors, which involves mandibular bone, the higher part of the medial pterygoid muscle, and the lateral pterygoid muscle.

RESULTS

Safe and sufficient excision of tumors was feasible by MPPO avoiding morbidities associated with mandibulotomy or lip-splitting without compromising oncological outcomes.

CONCLUSIONS

Although preliminary, our favorable outcomes indicate that MPPO might be a useful alternative to conventional mandibular swing approach or its modified procedures for selected cases with advanced oropharyngeal cancer. Further accumulation of data is encouraged.

摘要

目的

通过我们在咽旁间隙(PPS)手术中的经验,我们了解到仅通过经颈入路就有可能在靠近颅底处广泛暴露PPS。因此,我们推测,如果将这种经颈入路与经口入路相结合,对于晚期口咽癌的切除,一种无需下颌骨切开术和唇裂的侵入性较小的口咽切除术可能是可行的,从而避免了传统下颌骨摆动入路或其改良手术相关的并发症。我们将这种方法称为保留下颌骨的经口咽拉出式切除术(MPPO),并在这项前瞻性研究中评估其可行性和有效性。

材料与方法

MPPO应用于7例晚期外侧和/或上部口咽癌患者,其中包括2例T4期患者。我们目前对MPPO的应用排除了累及下颌骨、翼内肌上部和翼外肌的肿瘤。

结果

通过MPPO安全充分地切除肿瘤是可行的,避免了与下颌骨切开术或唇裂相关的并发症,且不影响肿瘤学疗效。

结论

尽管是初步研究,但我们良好的结果表明,对于某些晚期口咽癌病例,MPPO可能是传统下颌骨摆动入路或其改良手术的一种有用替代方法。鼓励进一步积累数据。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验