在B细胞慢性淋巴细胞白血病（B-CLL）和其他B细胞恶性肿瘤中增殖的B淋巴细胞常常倾向于产生天然自身抗体的证据。

Evidence that the B lymphocyte proliferating in B-CLL and in other B-cell malignancies is frequently committed to production of natural autoantibodies.

作者信息

Dighiero G, Borche L

机构信息

Immunohématologie et Immunopathologie, Institut Pasteur, Paris, France.

出版信息

Nouv Rev Fr Hematol (1978). 1990;32(5):323-6.

PMID:2099404

Abstract

Autoreactive B-cells constitute a substantial part of B-cell repertoire. They frequently secrete polyspecific natural autoantibodies which are the expression of germinal genes. During recent years, considerable evidence has accumulated indicating that autoreactive B-cells frequently undergo malignant transformation. This evidence arose from the study of monoclonal immunoglobulins (MIgs) and from recent studies of chronic lymphocytic leukemia (CLL) and non Hodgkin lymphoma (NHL) B lymphocytes. The present review, includes two sections. The first one reviews evidence supporting the idea that autoreactive B-cells constitute a substantial part of autoreactive B-cell repertoire. The second one is devoted to review evidence favouring the view that this autoreactive B-cell repertoire is frequently involved in B-cell malignancies.

摘要

自身反应性B细胞构成了B细胞库的很大一部分。它们经常分泌多特异性天然自身抗体，这些抗体是生发基因的表达产物。近年来，大量证据不断积累，表明自身反应性B细胞经常发生恶性转化。这一证据来自单克隆免疫球蛋白（MIgs）的研究以及近期对慢性淋巴细胞白血病（CLL）和非霍奇金淋巴瘤（NHL）B淋巴细胞的研究。本综述包括两个部分。第一部分回顾了支持自身反应性B细胞构成自身反应性B细胞库很大一部分这一观点的证据。第二部分致力于回顾支持这一自身反应性B细胞库经常参与B细胞恶性肿瘤这一观点的证据。