[来自健康成年人的巨噬细胞在接触鼠源性卡氏肺孢子虫后释放肿瘤坏死因子-α。初步研究]
[Macrophages from healthy adults release TNF-alpha after exposure to Pneumocystis carinii of murine origin. Preliminary study].
作者信息
Tamburrini E, De Luca A, Ventura G, Maiuro G, Siracusano A, Ortona E, Antinori A
机构信息
Istituto di Clinica delle Malattie Infettive, Università Cattolica del S. Cuore, Roma.
出版信息
Medicina (Firenze). 1990 Oct-Dec;10(4):393-4.
The ability of Pneumocystis carinii to induce TNF-alpha release by macrophages from adult healthy humans was investigated. Monocytes and monocytes derived macrophages produced an high amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid induced pneumocystosis. TNF-alpha release was P. carinii specific as shown by the inhibition exerted by the anti-P. carinii hyperimmune serum and it was not mediated by putative traces of endotoxin.
研究了卡氏肺孢子虫诱导健康成年人巨噬细胞释放肿瘤坏死因子-α（TNF-α）的能力。单核细胞和单核细胞衍生的巨噬细胞在暴露于从患有类固醇诱导性肺孢子虫病的大鼠中获得的卡氏肺孢子虫囊肿时，会产生大量的TNF-α。如抗卡氏肺孢子虫超免疫血清所发挥的抑制作用所示，TNF-α的释放具有卡氏肺孢子虫特异性，并且不是由假定的内毒素痕量介导的。
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