Mihalache M, Perţea M, Verbuţă A
Oficiul Farmaceutic Iaşi.
Rev Med Chir Soc Med Nat Iasi. 1990 Apr-Jun;94(2):389-92.
Our aim was to find a formulation for pyramidon suppositories in which the physicochemical compatibility of the active substance with the excipient to be the highest. Fatty and hydrosoluble excipients were studied. Following up in time the quality of the obtained preparation, it was concluded that the fatty substances are preferable, the suppositories with glycero-gelatinous mass being more stable by an one hour freezing and two hours freeze drying.
我们的目的是找到一种氨基比林栓剂的配方,使活性物质与辅料的物理化学相容性达到最高。对脂肪性和水溶性辅料进行了研究。通过及时跟踪所制备制剂的质量,得出脂肪性物质更可取的结论,含甘油明胶基质的栓剂在经过1小时冷冻和2小时冷冻干燥后更稳定。