Harrison R, Benboubetra M, Bryson S, Thomas R D, Elwood P C
Biochemistry Department, University of Bath.
Cardioscience. 1990 Sep;1(3):183-9.
Circulating antibodies to whole dried cows' milk, previously reported to be elevated in patients with myocardial infarction, have been shown to be directed mainly to the bovine milk fat globule membrane. Human antibodies against the bovine milk fat globule membrane themselves interact primarily with the enzyme, xanthine oxidase. Comparison of anti-(xanthine oxidase) antibody levels in 107 patients, who had suffered a myocardial infarction, with those in 86 control subjects showed significantly higher IgM levels in the patients with myocardial infarction. No corresponding differences were found for IgG or IgA anti-(xanthine oxidase) antibodies. Total levels of IgM class immunoglobulins did not differ between patients and controls. Serial assays following myocardial infarction showed no evidence that raised levels of IgM anti-(xanthine oxidase) antibodies result from the infarction itself.
先前有报道称，心肌梗死患者体内针对全脂干牛奶的循环抗体水平升高，现已证明这些抗体主要针对牛乳脂肪球膜。人类针对牛乳脂肪球膜的抗体本身主要与黄嘌呤氧化酶相互作用。对107名心肌梗死患者和86名对照者的抗（黄嘌呤氧化酶）抗体水平进行比较，结果显示心肌梗死患者的IgM水平显著更高。在IgG或IgA抗（黄嘌呤氧化酶）抗体方面未发现相应差异。患者和对照者之间IgM类免疫球蛋白的总水平没有差异。心肌梗死后的系列检测未发现证据表明IgM抗（黄嘌呤氧化酶）抗体水平升高是由梗死本身导致的。
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