Paul A M, Grundmann T, Sanchez-Hanke M
Asklepios Klinik Altona, Abteilung für HNO-Heilkunde, Hamburg.
Laryngorhinootologie. 2011 Feb;90(2):94-8. doi: 10.1055/s-0030-1267163. Epub 2010 Oct 28.
The mucosa of the middle ear and the Eustachian Tube changes in different ways when faced with recurrent episodes of inflammation. It thereby adapts to these new stimuli and insults from the environment. One of these changes is the development of MALT (mucosa associated lymphoid tissue). Another adaptation is an alteration of the epithelium. It was therefore the purpose of this study to look for a connection between the occurrence of these changes.
90 sections of temporal bones were examined under the light microscope and the incidence of MALT and nature of the epithelium found were compared.
Particularly in the middle ear, we demonstrated that in cases where MALT was found within the mucosa, columnar epithelium was frequently found in locations where it is typically rare. Squamous epithelium was in many cases replaced by cuboidal epithelium.
We demonstrated that the mucosa of the middle ear changed its morphology towards the characteristics typically found in the upper respiratory tract in cases where MALT had developed as subepithelial lymphoid follicles. It can therefore be concluded that both changes represent the mucosa's reaction to recurrent or chronic inflammation.
当中耳和咽鼓管黏膜面对反复的炎症发作时，会以不同方式发生变化。从而使其适应来自环境的这些新刺激和损伤。其中一种变化是黏膜相关淋巴组织（MALT）的形成。另一种适应方式是上皮细胞的改变。因此，本研究的目的是探寻这些变化之间的联系。
在光学显微镜下检查90个颞骨切片，并比较MALT的发生率和所发现的上皮细胞性质。
特别是在中耳，我们发现，在黏膜内发现有MALT的病例中，柱状上皮常在通常少见的部位出现。在许多情况下，鳞状上皮被立方上皮所取代。
我们证明，在中耳黏膜中，当MALT作为上皮下淋巴滤泡形成时，其形态会朝着在上呼吸道中常见的特征转变。因此可以得出结论，这两种变化均代表黏膜对反复或慢性炎症的反应。
