Department of Radiology, Louis Pradel Hospital, CREATIS, UMR CNRS 5515, INSERM U630, Lyon, France.
J Magn Reson Imaging. 2010 Nov;32(5):1110-6. doi: 10.1002/jmri.22384.
To assess the capability of four-dimensional (4D) time-resolved magnetic resonance angiography (MRA) to assess pulmonary arteriovenous malformations (PAVMs) patency by analyzing pulmonary arterial and venous enhancement kinetics.
Seven patients with eight documented patent PAVMs underwent a 4D-MRA with keyhole and viewsharing compression at 3T with the following parameters: spatial resolution 0.87 × 0.87 × 1.4 mm(3); field of view 500 × 350 × 238 mm(3); dynamic scan time (temporal resolution) 1.2 seconds; total acquisition time 18.1 seconds for six dynamic datasets (6 × 1.2 sec + reference scan: 10.9 sec). All images were reviewed by two experienced radiologists. Image quality was rated on a qualitative 5-point scale (1: not assessable to 5: excellent). Signal value was measured on cross-sectional planes for the afferent arteries and efferent veins of the PAVM, and for normal reference healthy arteries and veins. The difference in time to peak for each coupled artery/vein (dTTPav) was calculated and compared with a Mann-Whitney test between PAVMs and reference vessels.
Mean image quality was 3.2 ± 0.9. dTTPav was significantly smaller in PAVMs (0.15 ± 0.76 sec) than in reference vessels (3.75 ± 1.62 sec), P < 0.001.
4D-MRA is a promising tool for noninvasive assessment of PAVM patency.
通过分析肺动脉和静脉强化动力学，评估四维（4D）时间分辨磁共振血管造影（MRA）评估肺动静脉畸形（PAVM）通畅性的能力。
7 例 8 个经证实的通畅性 PAVM 患者在 3T 下接受 4D-MRA 检查，采用关键孔和视图共享压缩技术，参数如下：空间分辨率 0.87×0.87×1.4mm（3）；视野 500×350×238mm（3）；动态扫描时间（时间分辨率）1.2 秒；总采集时间 18.1 秒，用于 6 个动态数据集（6×1.2sec+参考扫描：10.9sec）。由两位有经验的放射科医生对所有图像进行了回顾。图像质量通过定性 5 分制进行评分（1：无法评估至 5：优秀）。在 PAVM 的输入动脉和输出静脉以及正常参考健康动脉和静脉的横断面上测量信号值。计算每个耦合动脉/静脉的达峰时间差（dTTPav），并使用 Mann-Whitney 检验在 PAVM 和参考血管之间进行比较。
平均图像质量为 3.2±0.9。PAVM 的 dTTPav 明显小于参考血管（0.15±0.76sec），P<0.001。
4D-MRA 是一种有前途的非侵入性评估 PAVM 通畅性的工具。
