Giangrande A, Palka J
Department of Zoology, University of Washington, Seattle 98195.
Semin Cell Biol. 1990 Jun;1(3):197-209.
The development of the peripheral nervous system (PNS) requires the activity of a number of genes. The neurogenic and the proneural genes are necessary in the earliest phase; their mutations lead to hyperplasia and partial or total elimination of the PNS respectively. Some of these mutations also affect other developmental processes. Other mutations affect later events: cut transforms one type of sensory organ into another; numb alters the fate of the components of a single sensory organ. We will describe the effects of the best studied mutations on PNS development and discuss the possible role of the wild type genes.
外周神经系统（PNS）的发育需要许多基因的参与。神经源性基因和原神经基因在最早阶段是必需的；它们的突变分别导致PNS增生以及部分或完全缺失。其中一些突变还会影响其他发育过程。其他突变则影响后期事件：cut基因可使一种感觉器官转变为另一种；numb基因会改变单个感觉器官组成部分的命运。我们将描述研究最深入的突变对PNS发育的影响，并讨论野生型基因可能发挥的作用。
