Department of Chemistry and Medical Chemistry, Yonsei University, Wonju 220-710, Korea.
Org Lett. 2010 Dec 3;12(23):5518-21. doi: 10.1021/ol1024037. Epub 2010 Nov 2.
2,2-Difluoro-1-tributylstannylethenyl p-toluenesulfonate (2) was reacted with aryl iodides in the presence of 10 mol % of Pd(PPh(3))(4) and 10 mol % of CuI in DMF at 80 °C for 10-20 h to give the cross-coupled products 3 in 35-97% yields. Further coupling reaction of 3 with arylstannanes in the presence of 5 mol % of Pd(PPh(3))(4) and 3 equiv of LiBr in DMF at 100 °C for 2-24 h afforded the desired products 5 in 25-78% yields.
2,2-二氟-1-三丁基锡烯基对甲苯磺酸盐（2）在 10 mol%的 Pd(PPh(3))(4)和 10 mol%的 CuI 的存在下，于 80°C 的 DMF 中与芳基碘化物反应 10-20 小时，以 35-97%的产率得到交叉偶联产物 3。在 5 mol%的 Pd(PPh(3))(4)和 3 当量的 LiBr 的存在下，3 与芳基锡烷的进一步偶联反应在 100°C 的 DMF 中反应 2-24 小时，以 25-78%的产率得到所需产物 5。
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