Department of Medicine, Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Am J Gastroenterol. 2011 Feb;106(2):229-40; quiz 241. doi: 10.1038/ajg.2010.429. Epub 2010 Nov 2.
Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct pathways, such as the serrated pathway, in which serrated polyps (including variants of hyperplastic polyps) are the precursor lesions. Approximately 15-20% of all CRCs arise via the serrated pathway, and these serrated carcinomas are clinically, morphologically, and molecularly distinct from conventional CRCs. The prevention of serrated carcinomas represents an important clinical challenge. Gastroenterologists need to recognize and remove potential precursor lesions and implement a post-polypectomy surveillance program when appropriate. This article focuses on the characteristics and significance of clinically relevant serrated polyps and addresses implications for CRC prevention practices.
结直肠癌（CRC）是一种异质性疾病，通过多种不同的途径发生，如锯齿状途径，其中锯齿状息肉（包括增生性息肉的变体）是前体病变。大约 15-20%的 CRC 通过锯齿状途径发生，这些锯齿状癌在临床、形态和分子上与传统的 CRC 不同。锯齿状癌的预防是一个重要的临床挑战。胃肠病学家需要识别和切除潜在的前体病变，并在适当的时候实施息肉切除后的监测计划。本文重点介绍了临床上相关的锯齿状息肉的特征和意义，并探讨了其对 CRC 预防实践的影响。
